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Probe for simultaneous membrane and nucleus labeling in living cells and in vivo bioimaging using a two-photon absorption water-soluble Zn(II) terpyridine complex with a reduced pi-conjugation system
Anhui University, Peoples R China.
Linköping University, Department of Physics, Chemistry and Biology, Surface Physics and Chemistry. Linköping University, Faculty of Science & Engineering. Anhui University, Peoples R China.
Anhui University, Peoples R China.
Linköping University, Department of Physics, Chemistry and Biology, Molecular Surface Physics and Nano Science. Linköping University, Faculty of Science & Engineering.
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2017 (English)In: Chemical Science, ISSN 2041-6520, E-ISSN 2041-6539, Vol. 8, no 1, 142-149 p.Article in journal (Refereed) Published
Abstract [en]

Small, biocompatible and water-soluble molecules with high two-photon absorption (2PA) cross-section values (delta) are in high demand for specific bioimaging applications. Here, two novel terpyridine derivative ligands with donor-acceptor (D-A) (L1) and donor-pi-acceptor (D-pi-A) (L2) models, and their corresponding Zn(II) complexes are designed and characterized. It was found that the two-photon absorption cross section values (d) in the near-infrared region (NIR, about 800 nm) are significantly enhanced for complexes 1 and 2 compared to their free D-A type ligand L1, while those of complexes 3 and 4 were greatly decreased relative to their free ligand L2, thus confirming that the smaller ligand (D-A type) displays a suitable Turn-ON fluorescence pair for two-photon fluorescence microscopy (2PFM). Firstly, the potential of simultaneously labeling a live cell plasma membrane and nucleus using complex 1 is demonstrated. In addition, live larval and adult zebrafish incubated with an optimal concentration of 1 demonstrated clear brain uptake. Lastly and importantly, using such a probe to visualize the blood-brain- barrier (BBB) capillary endothelial cells and penetrate the BBB into the central nervous system (CNS) intravenously in a mouse model is also explored.

Place, publisher, year, edition, pages
ROYAL SOC CHEMISTRY , 2017. Vol. 8, no 1, 142-149 p.
National Category
Organic Chemistry
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URN: urn:nbn:se:liu:diva-134487DOI: 10.1039/c6sc02342hISI: 000391454500013OAI: oai:DiVA.org:liu-134487DiVA: diva2:1074417
Note

Funding Agencies|National Natural Science Foundation of China [51372003, 21271004, 51432001, 21271003, 21501001]; Ministry of Education; Anhui University Doctor Startup Fund [J01001962]; Higher Education Revitalization Plan Talent Project; China Postdoctoral Science Foundation [2015M571912]

Available from: 2017-02-15 Created: 2017-02-15 Last updated: 2017-11-29

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