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Autosomal and X-Linked Additive Genetic Variation for Lifespan and Aging: Comparisons Within and Between the Sexes in Drosophila melanogaster
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Ecology and Genetics, Evolutionary Biology. Univ Turku, Dept Biol, Turku 20014, Finland..
Univ Bielefeld, Dept Evolutionary Biol, D-33615 Bielefeld, Germany.;Friedrich Schiller Univ Jena, Inst Ecol, Dept Populat Ecol, D-07743 Jena, Germany..
Linkoping Univ, AVIAN Behav Genom & Physiol Grp, IFM Biol, S-58183 Linkoping, Sweden..
2016 (English)In: G3: Genes, Genomes, Genetics, ISSN 2160-1836, E-ISSN 2160-1836, Vol. 6, no 12, 3903-3911 p.Article in journal (Refereed) Published
Abstract [en]

Theory makes several predictions concerning differences in genetic variation between the X chromosome and the autosomes due to male X hemizygosity. The X chromosome should: (i) typically show relatively less standing genetic variation than the autosomes, (ii) exhibit more variation in males compared to females because of dosage compensation, and (iii) potentially be enriched with sex-specific genetic variation. Here, we address each of these predictions for lifespan and aging in Drosophila melanogaster. To achieve unbiased estimates of X and autosomal additive genetic variance, we use 80 chromosome substitution lines; 40 for the X chromosome and 40 combining the two major autosomes, which we assay for sex-specific and cross-sex genetic (co)variation. We find significant X and autosomal additive genetic variance for both traits in both sexes (with reservation for X-linked variation of aging in females), but no conclusive evidence for depletion of X-linked variation (measured through females). Males display more X-linked variation for lifespan than females, but it is unclear if this is due to dosage compensation since also autosomal variation is larger in males. Finally, our results suggest that the X chromosome is enriched for sex-specific genetic variation in lifespan but results were less conclusive for aging overall. Collectively, these results suggest that the X chromosome has reduced capacity to respond to sexually concordant selection on lifespan from standing genetic variation, while its ability to respond to sexually antagonistic selection may be augmented.

Place, publisher, year, edition, pages
2016. Vol. 6, no 12, 3903-3911 p.
Keyword [en]
dosage compensation, faster X, intersexual genetic correlation, sexual dimorphism, X chromosome
National Category
Evolutionary Biology Genetics
Identifiers
URN: urn:nbn:se:uu:diva-313968DOI: 10.1534/g3.116.028308ISI: 000390591400012PubMedID: 27678519OAI: oai:DiVA.org:uu-313968DiVA: diva2:1072721
Funder
The Royal Swedish Academy of SciencesGerman Research Foundation (DFG), SCHI 1188/1-1Swedish Research CouncilSwedish Foundation for Strategic Research Lars Hierta Memorial Foundation
Available from: 2017-02-08 Created: 2017-01-25 Last updated: 2017-11-29Bibliographically approved

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