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A systematic review of resting-state functional-MRI studies in anorexia nervosa: Evidence for functional connectivity impairment in cognitive control and visuospatial and body-signal integration
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Functional Pharmacology. Univ Campus Biomed Roma, Ctr Integrated Res, Area Diagnost Imaging, Via Alvaro Portillo 200, I-00133 Rome, Italy..
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Functional Pharmacology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Functional Pharmacology. Univ Cape Town, Dept Psychiat & Mental Hlth, Old Groote Schuur Hosp, Psychiat Neuroimaging Grp, Anzio Rd, ZA-7925 Cape Town, South Africa..
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Functional Pharmacology.
2016 (English)In: Neuroscience and Biobehavioral Reviews, ISSN 0149-7634, E-ISSN 1873-7528, Vol. 71, p. 578-589Article, review/survey (Refereed) Published
Abstract [en]

This paper systematically reviews the literature pertaining to the use of resting-state functional magnetic resonance imaging (rsfMRI) in anorexia nervosa (AN), classifying studies on the basis of different analysis approaches. We followed PRISMA guidelines. Fifteen papers were included, investigating a total of 294 participants with current or past AN and 285 controls. The studies used seed-based, whole-brain independent component analysis (ICA), network-of-interest ICA based and graph analysis approaches. The studies showed relatively consistent overlap in results, yet little overlap in their analytical approach and/or a-priori assumptions. Functional connectivity alterations were mainly found in the corticolimbic circuitry, involved in cognitive control and visual and homeostatic integration. Some overlapping findings were found in brain areas putatively important in AN, such as the insula. These results suggest altered functional connectivity in networks/areas linked to the main symptom domains of AN, such as impaired cognitive control and body image disturbances. These preliminary evidences suggest that more targeted treatments need to be developed that focus on these two symptom domains. Further studies with multi-approach analyses and longitudinal designs are needed to better understand the complexity of AN.

Place, publisher, year, edition, pages
2016. Vol. 71, p. 578-589
Keywords [en]
Eating disorders, Anorexia nervosa, Neuroimaging, Resting-state, Default mode network, Insula, Cognitive control, Body image disturbances
National Category
Neurology
Identifiers
URN: urn:nbn:se:uu:diva-314809DOI: 10.1016/j.neubiorev.2016.09.032ISI: 000390502100038PubMedID: 27725172OAI: oai:DiVA.org:uu-314809DiVA, id: diva2:1072225
Available from: 2017-02-07 Created: 2017-02-06 Last updated: 2017-11-29Bibliographically approved

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