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Synthetic bone grafts for treatment of femoral head necrosis
Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - Ångström, Inorganic Chemistry.
2017 (English)Independent thesis Advanced level (professional degree), 20 credits / 30 HE creditsStudent thesis
Abstract [en]

Necrosis of the femoral head is a relatively common medical condition that radically

decrease the quality of life for the patient. Left untreated it could lead to destruction

of the hip joint. A common treatment is using bone autografts, also called bone chips.

However, in the last decades synthetic bone grafts have become a very interesting

alternative. This thesis had two aims; to evaulate how porous hydroxyapatite grafts

with varied pore size could be produced by different size of the porogen and to

create two-phase cements which would form pores in situ by using a dissolvable

phase of calcium sulfate hemihydrate. The phase composition, morphology, porosity

and pore size distribution were characterized with x-ray diffraction, scanning electron

microscopy and micro-computed tomography. It was found that hydroxyapatite

granules could be produced and it was possible to vary their pore size to some extent

by changing the size of the porogen. At physiological temperature, pores were formed

in the two-phase cements from one week and onwards.

Place, publisher, year, edition, pages
2017. , 45 p.
UPTEC K, ISSN 1650-8297 ; 17003
National Category
Chemical Engineering
URN: urn:nbn:se:uu:diva-314857OAI: diva2:1071947
Educational program
Master Programme in Chemical Engineering
Available from: 2017-02-07 Created: 2017-02-07Bibliographically approved

Open Access in DiVA

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