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Patient-reported outcomes and visual acuity after 12 months of anti-VEGF-treatment for sight-threatening diabetic macular edema in a real world setting
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Clinical diabetology and metabolism. Dalarna Univ, Sch Educ Hlth & Social Studies, Falun, Sweden.
Dalarna Univ, Sch Educ Hlth & Social Studies, Falun, Sweden..
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Clinical diabetology and metabolism. Söder Sjukhuset, Sachs Children & Youth Hosp, Stockholm, Sweden.;Söder Sjukhuset, Karolinska Inst, Dept Clin Res & Educ, Stockholm, Sweden..
Dalarna Cty Hosp, Dept Ophthalmol, Falun, Sweden..
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2016 (English)In: Diabetes Research and Clinical Practice, ISSN 0168-8227, E-ISSN 1872-8227, Vol. 121, p. 157-165Article in journal (Refereed) Published
Abstract [en]

Aims: To examine objective visual acuity measured with ETDRS, retinal thickness (OCT), patient reported outcome and describe levels of glycated hemoglobin and its association with the effects on visual acuity in patients treated with anti-VEGF for visual impairment due to diabetic macular edema (DME) during 12 months in a real world setting.

Methods: In this cross-sectional study, 58 patients (29 females and 29 males; mean age, 68 years) with type 1 and type 2 diabetes diagnosed with DME were included. Medical data and two questionnaires were collected; an eye-specific (NEI VFQ-25) and a generic health-related quality of life questionnaire (SF-36) were used.

Results: The total patient group had significantly improved visual acuity and reduced retinal thickness at 4 months and remains at 12 months follow up. Thirty patients had significantly improved visual acuity, and 27 patients had no improved visual acuity at 12 months. The patients with improved visual acuity had significantly improved scores for NEI VFQ-25 subscales including general health, general vision, near activities, distance activities, and composite score, but no significant changes in scores were found in the group without improvements in visual acuity.

Conclusions: Our study revealed that anti-VEGF treatment improved visual acuity and central retinal thickness as well as patient-reported outcome in real world 12 months after treatment start.

Place, publisher, year, edition, pages
2016. Vol. 121, p. 157-165
Keywords [en]
Patient-reported measurements, Diabetic macular edema, Anti-VEGF treatment, Visual function
National Category
Endocrinology and Diabetes
Identifiers
URN: urn:nbn:se:uu:diva-313411DOI: 10.1016/j.diabres.2016.09.015ISI: 000390460100020PubMedID: 27718374OAI: oai:DiVA.org:uu-313411DiVA, id: diva2:1069698
Funder
Magnus Bergvall FoundationAvailable from: 2017-01-30 Created: 2017-01-19 Last updated: 2017-11-29Bibliographically approved

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Granström, ThereseOlinder, Anna LindholmEriksson, Jan W.Granstam, ElisabetLeksell, Janeth
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Clinical diabetology and metabolismCentre for Clinical Research, County of Västmanland
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