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Assessment of turbulent viscous stress using ICOSA 4D Flow MRI for prediction of hemodynamic blood damage
Linköping University, Department of Medical and Health Sciences, Division of Cardiovascular Medicine. Linköping University, Faculty of Medicine and Health Sciences.
Linköping University, Department of Medical and Health Sciences, Division of Cardiovascular Medicine. Linköping University, Faculty of Medicine and Health Sciences.ORCID iD: 0000-0003-1942-7699
University of Calif San Francisco, CA 94143 USA.
Linköping University, Department of Medical and Health Sciences, Division of Cardiovascular Medicine. Linköping University, Faculty of Medicine and Health Sciences.
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2016 (English)In: SCIENTIFIC REPORTS, ISSN 2045-2322, Vol. 6, article id 39773Article in journal (Refereed) Published
Abstract [en]

Flow-induced blood damage plays an important role in determining the hemodynamic impact of abnormal blood flow, but quantifying of these effects, which are dominated by shear stresses in highly fluctuating turbulent flow, has not been feasible. This study evaluated the novel application of turbulence tensor measurements using simulated 4D Flow MRI data with six-directional velocity encoding for assessing hemodynamic stresses and corresponding blood damage index (BDI) in stenotic turbulent blood flow. The results showed that 4D Flow MRI underestimates the maximum principal shear stress of laminar viscous stress (PLVS), and overestimates the maximum principal shear stress of Reynolds stress (PRSS) with increasing voxel size. PLVS and PRSS were also overestimated by about 1.2 and 4.6 times at medium signal to noise ratio (SNR) = 20. In contrast, the square sum of the turbulent viscous shear stress (TVSS), which is used for blood damage index (BDI) estimation, was not severely affected by SNR and voxel size. The square sum of TVSS and the BDI at SNR amp;gt;20 were underestimated by less than 1% and 10%, respectively. In conclusion, this study demonstrated the feasibility of 4D Flow MRI based quantification of TVSS and BDI which are closely linked to blood damage.

Place, publisher, year, edition, pages
NATURE PUBLISHING GROUP , 2016. Vol. 6, article id 39773
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Fluid Mechanics and Acoustics
Identifiers
URN: urn:nbn:se:liu:diva-134077DOI: 10.1038/srep39773ISI: 000390867800001PubMedID: 28004789OAI: oai:DiVA.org:liu-134077DiVA, id: diva2:1068906
Note

Funding Agencies|European Research Council [310612]; Swedish Research Council [2013-6077, 2014-6191]; National Research Foundation of Korea (NRF) - Ministry of Education [2016R1A6A3A03006337]

Available from: 2017-01-26 Created: 2017-01-22 Last updated: 2017-05-03

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Ha, HojinLantz, JonasCasas Garcia, BelénZiegler, MagnusKarlsson, MattsDyverfeldt, PetterEbbers, Tino
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Division of Cardiovascular MedicineFaculty of Medicine and Health SciencesApplied Thermodynamics and Fluid MechanicsFaculty of Science & EngineeringCenter for Medical Image Science and Visualization (CMIV)Department of Clinical Physiology in Linköping
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