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Anionic Oligothiophenes Compete for Binding of X-34 but not PIB to Recombinant A beta Amyloid Fibrils and Alzheimers Disease Brain-Derived A beta
Linköping University, Department of Physics, Chemistry and Biology, Chemistry. Linköping University, Faculty of Science & Engineering.
Linköping University, Department of Physics, Chemistry and Biology, Chemistry. Linköping University, Faculty of Science & Engineering.
University of Kentucky, KY 40536 USA.
Linköping University, Department of Physics, Chemistry and Biology, Chemistry. Linköping University, Faculty of Science & Engineering.ORCID iD: 0000-0002-5582-140X
2016 (English)In: CHEMISTRY-A EUROPEAN JOURNAL, ISSN 0947-6539, Vol. 22, no 51, p. 18335-18338Article in journal (Refereed) Published
Abstract [en]

Deposits comprised of amyloid- (A) are one of the pathological hallmarks of Alzheimers disease (AD) and small hydrophobic ligands targeting these aggregated species are used clinically for the diagnosis of AD. Herein, we observed that anionic oligothiophenes efficiently displaced X-34, a Congo Red analogue, but not Pittsburgh compoundB (PIB) from recombinant A amyloid fibrils and Alzheimers disease brain-derived A. Overall, we foresee that the oligothiophene scaffold offers the possibility to develop novel high-affinity ligands for A pathology only found in human AD brain, targeting a different site than PIB.

Place, publisher, year, edition, pages
WILEY-V C H VERLAG GMBH , 2016. Vol. 22, no 51, p. 18335-18338
Keywords [en]
Alzheimers disease; amyloid ligands; fluorescence; luminescent conjugated oligothiophenes; proteins
National Category
Pharmaceutical Sciences
Identifiers
URN: urn:nbn:se:liu:diva-134083DOI: 10.1002/chem.201604583ISI: 000390600900006PubMedID: 27767229OAI: oai:DiVA.org:liu-134083DiVA, id: diva2:1068890
Note

Funding Agencies|Swedish Foundation for Strategic Research; Erling Persson foundation; Coins for Alzheimers Research Trust (C.A.R.T.); NIH [R21 NS080576]

Available from: 2017-01-26 Created: 2017-01-22 Last updated: 2018-01-13

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