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How Did Zika Virus Emerge in the Pacific Islands and Latin America?
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology. Norwegian Inst Publ Hlth, Domain Infect Control & Environm Hlth, Dept Infect Dis Epidemiol & Modelling Mol Biol, Oslo, Norway.
Norwegian Inst Publ Hlth, Domain Infect Control & Environm Hlth, Dept Infect Dis Epidemiol & Modelling Mol Biol, Oslo, Norway..
Rockefeller Univ, St Giles Lab Human Genet Infect Dis, 1230 York Ave, New York, NY 10021 USA.;New York Med Coll, Dept Microbiol & Immunol, Valhalla, NY 10595 USA..
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology.
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2016 (English)In: mBio, ISSN 2161-2129, E-ISSN 2150-7511, Vol. 7, no 5, article id e01239-16Article in journal (Refereed) Published
Abstract [en]

The unexpected emergence of Zika virus (ZIKV) in the Pacific Islands and Latin America and its association with congenital Zika virus syndrome (CZVS) (which includes microcephaly) and Guillain-Barre syndrome (GBS) have stimulated wide-ranging research. High densities of susceptible Aedes spp., immunologically naive human populations, global population growth with increased urbanization, and escalation of global transportation of humans and commercial goods carrying vectors and ZIKV undoubtedly enhanced the emergence of ZIKV. However, flavivirus mutations accumulate with time, increasing the likelihood that genetic viral differences are determinants of change in viral phenotype. Based on comparative ZIKV complete genome phylogenetic analyses and temporal estimates, we identify amino acid substitutions that may be associated with increased viral epidemicity, CZVS, and GBS. Reverse genetics, vector competence, and seroepidemiological studies will test our hypothesis that these amino acid substitutions are determinants of epidemic and neurotropic ZIKV emergence.

Place, publisher, year, edition, pages
2016. Vol. 7, no 5, article id e01239-16
National Category
Microbiology in the medical area
Identifiers
URN: urn:nbn:se:uu:diva-313422DOI: 10.1128/mBio.01239-16ISI: 000390132900056OAI: oai:DiVA.org:uu-313422DiVA, id: diva2:1067846
Funder
EU, FP7, Seventh Framework Programme, 278433EU, Horizon 2020, 653316
Note

Erratum in mBio Mar 2018, 9 (2) e00386-18

DOI: https://doi.org/10.1128/mbio.00386-18

Available from: 2017-01-23 Created: 2017-01-19 Last updated: 2018-08-28Bibliographically approved

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