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Autosomal and X-Linked Additive Genetic Variation for Lifespan and Aging: Comparisons Within and Between the Sexes in Drosophila melanogaster
Uppsala University, Sweden; University of Turku, Finland.
University of Bielefeld, Germany; Friedrich Schiller University of Jena, Germany.
Linköping University, Department of Physics, Chemistry and Biology, Biology. Linköping University, Faculty of Science & Engineering.ORCID iD: 0000-0001-6112-9586
2016 (English)In: G3-GENES GENOMES GENETICS, ISSN 2160-1836, Vol. 6, no 12, p. 3903-3911Article in journal (Refereed) Published
Abstract [en]

Theory makes several predictions concerning differences in genetic variation between the X chromosome and the autosomes due to male X hemizygosity. The X chromosome should: (i) typically show relatively less standing genetic variation than the autosomes, (ii) exhibit more variation in males compared to females because of dosage compensation, and (iii) potentially be enriched with sex-specific genetic variation. Here, we address each of these predictions for lifespan and aging in Drosophila melanogaster. To achieve unbiased estimates of X and autosomal additive genetic variance, we use 80 chromosome substitution lines; 40 for the X chromosome and 40 combining the two major autosomes, which we assay for sex-specific and cross-sex genetic (co)variation. We find significant X and autosomal additive genetic variance for both traits in both sexes (with reservation for X-linked variation of aging in females), but no conclusive evidence for depletion of X-linked variation (measured through females). Males display more X-linked variation for lifespan than females, but it is unclear if this is due to dosage compensation since also autosomal variation is larger in males. Finally, our results suggest that the X chromosome is enriched for sex-specific genetic variation in lifespan but results were less conclusive for aging overall. Collectively, these results suggest that the X chromosome has reduced capacity to respond to sexually concordant selection on lifespan from standing genetic variation, while its ability to respond to sexually antagonistic selection may be augmented.

Place, publisher, year, edition, pages
GENETICS SOCIETY AMERICA , 2016. Vol. 6, no 12, p. 3903-3911
Keywords [en]
dosage compensation; faster X; intersexual genetic correlation; sexual dimorphism; X chromosome
National Category
Evolutionary Biology
Identifiers
URN: urn:nbn:se:liu:diva-134089DOI: 10.1534/g3.116.028308ISI: 000390591400012PubMedID: 27678519OAI: oai:DiVA.org:liu-134089DiVA, id: diva2:1067530
Note

Funding Agencies|Swedish Royal Academy of Sciences; Lars Hiertas Minne foundation; German Research Foundation (DFG) [SCHI 1188/1-1]; Swedish Research Council; Swedish Foundation for Strategic Research

Available from: 2017-01-22 Created: 2017-01-22 Last updated: 2017-02-14

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