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Sublingual administration of atropine eyedrops in children with excessive drooling - a pilot study
Institute Postgrad Dent Educ, Sweden; Jonköping University, Sweden.
Linköping University, Department of Clinical and Experimental Medicine, Division of Neuro and Inflammation Science. Linköping University, Faculty of Medicine and Health Sciences.
Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Anaesthetics, Operations and Specialty Surgery Center, Maxillofacial Unit. Linköping University, Department of Clinical and Experimental Medicine, Division of Surgery, Orthopedics and Oncology.
Ryhov County Hospital, Sweden.
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2017 (English)In: International Journal of Paediatric Dentistry, ISSN 0960-7439, E-ISSN 1365-263X, Vol. 27, no 1, p. 22-29Article in journal (Refereed) Published
Abstract [en]

BackgroundDrooling can be a severe disability and have high impact on daily life. Reversible treatment is preferable. AimTo analyse whether sublingual administration of atropine eyedrops is a useful reversible treatment option for severe drooling in children with disabilities. DesignThe study had a prospective, single-system research design. The participants served as their own controls. The study period was 3 weeks without treatment, 4 weeks with atropine eyedrop solution 10 mg/mL one drop a day followed by 4 weeks of one drop twice a day. Parents rating of their childs drooling was assessed on a 100-mm VAS, and unstimulated salivary secretion rate measurement was performed together with notations about side effects and practicality. ResultsParents VAS assessment of drooling decreased from a median (range) of 74 (40-98) at baseline to 48 (18-88) (P = 0.05) and 32 (12-85) (P = 0.004) after 4 weeks of atropine once a day and another 4 weeks of atropine twice a day, respectively (n = 11). Unstimulated salivary secretion rates decreased from baseline to end of study (P = 0.032). Several parents complained about difficult administration. No irreversible side effects were noted. ConclusionsSublingual atropine eyedrops may be an alternative for treatment of severe drooling in children with disabilities.

Place, publisher, year, edition, pages
WILEY-BLACKWELL , 2017. Vol. 27, no 1, p. 22-29
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Dentistry
Identifiers
URN: urn:nbn:se:liu:diva-133882DOI: 10.1111/ipd.12219ISI: 000389925200005PubMedID: 26708211OAI: oai:DiVA.org:liu-133882DiVA, id: diva2:1065117
Note

Funding Agencies|FORSS, Medical Research Council of Southeast Sweden; Public Dental Health, Region Ostergotland, Sweden

Available from: 2017-01-13 Created: 2017-01-13 Last updated: 2018-05-07

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Graf, JonasMarcusson, AgnetaSjöstrand, EvaBågesund, Mats
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Division of Neuro and Inflammation ScienceFaculty of Medicine and Health SciencesMaxillofacial UnitDivision of Surgery, Orthopedics and OncologyDepartment of Clinical and Experimental MedicineDepartment of Child and Adolescent HabilitationDivision of Cardiovascular MedicinePublic Dental Health Care
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