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Overexpression of Psoriasin (S100A7) Contributes to Dysregulated Differentiation in Psoriasis.
Linköping University, Department of Clinical and Experimental Medicine, Division of Neuro and Inflammation Science. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Heart and Medicine Center, Department of Dermatology and Venerology. (Ingrid Asp Psoriasis Research Center)
Linköping University, Department of Clinical and Experimental Medicine, Division of Neuro and Inflammation Science. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Heart and Medicine Center, Department of Dermatology and Venerology. (Ingrid Asp Psoriasis Research Center)
Linköping University, Department of Clinical and Experimental Medicine, Division of Cell Biology. Linköping University, Faculty of Medicine and Health Sciences. (Ingrid Asp Psoriasis Research Center)
Linköping University, Department of Clinical and Experimental Medicine, Division of Cell Biology. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Heart and Medicine Center, Department of Dermatology and Venerology. (Ingrid Asp Psoriasis Research Center)
2017 (English)In: Acta Dermato-Venereologica, ISSN 0001-5555, E-ISSN 1651-2057, Vol. 97, no 4, p. 441-448Article in journal (Refereed) Published
Abstract [en]

Psoriasin, which is highly expressed in psoriasis, is encoded by a gene located within the epidermal differentiation complex. The aim of this study was to investigate the effect of endogenous psoriasin on disturbed keratinocyte differentiation in psoriasis. Immunohistochemical staining revealed a gradient of psoriasin expression in the psoriatic epidermis with highest expression in the suprabasal, differentiated layers. Induction of keratinocyte differentiation caused concurrent expression of psoriasin and the differentiation marker involucrin. The differentiation-induced psoriasin expression was found to be mediated by the protein kinase C pathway. The downregulation of psoriasin expression by small interfering RNA revealed that psoriasin mediates the expression of involucrin, desmoglein 1, transglutaminase 1 and CD24 in normal differentiation. The lentivirus-mediated overexpression of psoriasin, mimicking the psoriatic milieu, gave rise to an altered regulation of differentiation genes and an expression pattern reminiscent of that in psoriatic epidermis. These findings suggest that psoriasin contributes to the dysregulated differentiation process in the psoriasis epidermis.

Place, publisher, year, edition, pages
Society for the Publication of Acta Dermato - Venereologica , 2017. Vol. 97, no 4, p. 441-448
National Category
Dermatology and Venereal Diseases
Identifiers
URN: urn:nbn:se:liu:diva-133860DOI: 10.2340/00015555-2596ISI: 000401127000005PubMedID: 27958610OAI: oai:DiVA.org:liu-133860DiVA, id: diva2:1064659
Note

Funding agencies: Ingrid Asp Foundation; Welander Foundation; Swedish psoriasis association; Medical Research Council

Available from: 2017-01-12 Created: 2017-01-12 Last updated: 2018-05-02Bibliographically approved

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Ekman, Anna-KarinVegfors, JennyBivik, CeciliaEnerbäck, Charlotta
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