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In vitro biological responses to nanofibrillated cellulose by human dermal, lung and immune cells: surface chemistry aspect
Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Nanotechnology and Functional Materials. (Nanoteknologi och funktionella material)ORCID iD: 0000-0003-2079-4170
UCL Inst Ophthalmol, Ocular Biol & Therapeut, 11-43 Bath St, London EC1V 9EL, England.
Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Nanotechnology and Functional Materials. (Nanoteknologi och funktionella material)ORCID iD: 0000-0002-5496-9664
Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Nanotechnology and Functional Materials. (Nanotechnology and Functional Materials)
2017 (English)In: Particle and Fibre Toxicology, ISSN 1743-8977, E-ISSN 1743-8977, Vol. 14, article id 1Article in journal (Refereed) Published
Abstract [en]

Nanocellulose, and particularly nanofibrillated cellulose (NFC), has been proposed for a diversity of applications in industry and in the biomedical field. Its unique physicochemical and structural features distinguish nanocellulose from traditional materials and enable its use as an advance nanomaterial. However, its nanoscale features may induce unknown biological responses. Limited studies with NFC are available and the biological impacts of its use have not been thoroughly explored. This study assesses the in vitro biological responses elicited by wood-derived NFC gels, when human dermal fibroblasts, lung MRC-5 cells and THP-1 macrophage cells are exposed to the nanomaterial. Furthermore, whether the presence of surface charged groups (i.e. carboxymethyl and hydroxypropyltrimethylammonium groups) on NFC can induce distinct biological responses is investigated.

Place, publisher, year, edition, pages
2017. Vol. 14, article id 1
Keywords [en]
Cytotoxicity, Inflammation, Nanocellulose, Surface chemistry
National Category
Nano Technology
Research subject
Engineering Science with specialization in Nanotechnology and Functional Materials
Identifiers
URN: urn:nbn:se:uu:diva-312570DOI: 10.1186/s12989-016-0182-0ISI: 000396292900001PubMedID: 28069023OAI: oai:DiVA.org:uu-312570DiVA, id: diva2:1064064
Funder
Swedish Research Council Formas, 2014-151Lars Hierta Memorial Foundation, FO2014-0437Stiftelsen Olle Engkvist Byggmästare, 2014/457EU, FP7, Seventh Framework Programme, 604387Available from: 2017-01-11 Created: 2017-01-11 Last updated: 2017-11-29Bibliographically approved

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Lopes, VivianaStrömme, MariaFerraz, Natalia
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