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Macular function in preterm children at school age
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Ophthalmology.
Univ Lund Hosp, Dept Ophthalmol, S-22185 Lund, Sweden..
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Ophthalmology.
2016 (English)In: Documenta Ophthalmologica, ISSN 0012-4486, E-ISSN 1573-2622, Vol. 133, no 3, p. 151-157Article in journal (Refereed) Published
Abstract [en]

Macular development is a complex process that starts by mid-gestation and continues several years after birth. A preterm birth could affect this development, causing increased thickness in the central macula, but the effect of the macular function remains uncertain. The aim of this study was to investigate the macular function measured with multifocal electroretinography (mfERG), in former preterm children and compare with healthy controls. A second aim was to correlate central macular function with central macular thickness measured with optical coherent tomography (OCT), in the preterm group. Fifteen former preterm children born before 32 weeks of gestation were included in the study. MfERG results from 12 children acted as controls. Visual acuity, refraction in cycloplegia and mfERG were carried out in all children, and optical coherent tomography (OCT) was performed in the preterm children. Main outcomes were P1 amplitudes and implicit times for Rings 1-5 and "sum of groups" of the mfERG, and central macula thickness in area A1 measured with OCT. The P1 amplitudes were reduced in Rings 1-5 and "Sum of groups" in the preterm children compared to controls. There were no significant correlation between P1 amplitude or implicit times in Ring 1 and central macular thickness in the preterm group. Macular function is reduced in former preterm children compared to children born at term. This suggests that the structural changes with a thicker central retina can have an effect on function and may be one, of probably several, explanations for visual dysfunction in preterm children at school age.

Place, publisher, year, edition, pages
2016. Vol. 133, no 3, p. 151-157
Keyword [en]
Macula, Multifocal electroretinogram (mfERG), Optical coherent tomography (OCT), Preterm children
National Category
Ophthalmology
Identifiers
URN: urn:nbn:se:uu:diva-312049DOI: 10.1007/s10633-016-9564-8ISI: 000388974900001PubMedID: 27838859OAI: oai:DiVA.org:uu-312049DiVA, id: diva2:1062349
Available from: 2017-01-05 Created: 2017-01-04 Last updated: 2017-11-29Bibliographically approved

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