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Studying the Cohesion Evolution of Genes Related to Chronic Lymphocytic Leukemia Using Semantic Similarity in Gene Ontology and Self-Organizing Maps
University of Borås, Faculty of Librarianship, Information, Education and IT.
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2016 (English)In: Proceedings of SWAT4LS-16, 9th International Conference on Semantic Web Applications and Tools for Life Sciences, 2016Conference paper, Published paper (Refereed)
Abstract [en]

A significant body of work on biomedical text mining is aimed at uncovering meaningful associations between biological entities, including genes. This has the potential to offer new insights for research, uncovering hidden links between genes involved in critical pathways and processes. Recently, high-throughput studies have started to unravel the genetic landscape of chronic lymphocytic leukemia (CLL), the most common adult leukemia. CLL displays remarkable clinical heterogeneity, likely reflecting its underlying biological heterogeneity which, despite all progress, still remains insufficiently characterized and understood. This paper deploys an ontology-based semantic similarity combined with self-organizing maps for studying the temporal evolution of cohesion among CLL-related genes and the extracted information. Three consecutive time periods are considered and groups of genes are derived therein. Our preliminary results indicated that our proposed gene groupings are meaningful and that the temporal dimension indeed impacted the gene cohesion, leaving a lot of room for further promising investigations.

Place, publisher, year, edition, pages
2016.
Keywords [en]
Chronic Lymphocytic Leukemia, Gene Ontology, Semantic Similarity, Semantic Drift, Self-Organizing Maps
National Category
Other Computer and Information Science
Identifiers
URN: urn:nbn:se:hb:diva-11650OAI: oai:DiVA.org:hb-11650DiVA, id: diva2:1062327
Conference
9th International Conference on Semantic Web Applications and Tools for Life Sciences, Amsterdam, December 5-8, 2016
Available from: 2017-01-05 Created: 2017-01-05 Last updated: 2018-01-13Bibliographically approved

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Darányi, SándorWittek, Peter
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CiteExportLink to record
Permanent link

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Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
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  • nn-NO
  • nn-NB
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  • Other locale
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Output format
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