Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Hybrid Microfluidic Platform for Multifactorial Analysis Based on Electrical Impedance, Refractometry, Optical Absorption and Fluorescence
University of Nova Lisboa, Portugal; CEMOP UNINOVA, Portugal; University of Nova Lisboa, Portugal.
Linköping University, Department of Science and Technology, Physics and Electronics. Linköping University, Faculty of Science & Engineering. University of Nova Lisboa, Portugal; CEMOP UNINOVA, Portugal.
University of Porto, Portugal; Institute Syst and Comp Engn Technology and Science INESC TEC, Portugal.
University of Nova Lisboa, Portugal; CEMOP UNINOVA, Portugal.
Show others and affiliations
2016 (English)In: Micromachines, ISSN 2072-666X, E-ISSN 2072-666X, Vol. 7, no 10, article id 181Article in journal (Refereed) Published
Abstract [en]

This paper describes the development of a novel microfluidic platform for multifactorial analysis integrating four label-free detection methods: electrical impedance, refractometry, optical absorption and fluorescence. We present the rationale for the design and the details of the microfabrication of this multifactorial hybrid microfluidic chip. The structure of the platform consists of a three-dimensionally patterned polydimethylsiloxane top part attached to a bottom SU-8 epoxy-based negative photoresist part, where microelectrodes and optical fibers are incorporated to enable impedance and optical analysis. As a proof of concept, the chip functions have been tested and explored, enabling a diversity of applications: (i) impedance-based identification of the size of micro beads, as well as counting and distinguishing of erythrocytes by their volume or membrane properties; (ii) simultaneous determination of the refractive index and optical absorption properties of solutions; and (iii) fluorescence-based bead counting.

Place, publisher, year, edition, pages
MDPI AG , 2016. Vol. 7, no 10, article id 181
Keyword [en]
single cell analysis; label-free methods; impedance spectroscopy; refractometry; optical absorption; hybrid microfluidic chip
National Category
Other Medical Engineering
Identifiers
URN: urn:nbn:se:liu:diva-133534DOI: 10.3390/mi7100181ISI: 000389131300011OAI: oai:DiVA.org:liu-133534DiVA, id: diva2:1060861
Note

Funding Agencies|FEDER funds through the COMPETE 2020 Programme; National Funds through Fundacao para a Ciencia e a Tecnologia (FCT) [UID/CTM/50025/2013, PTDC/SAU-BEB/102247/2008]; project "Project" NanoSTIMA: Macro-to-Nano Human Sensing: Towards Integrated Multimodal Health Monitoring and Analytics - North Portugal Regional Operational Programme [NORTE-01-0145-FEDER-000016]; European Regional Development Fund (ERDF); North Portugal Regional Operational Program under the National Strategic Reference Framework (NSRF), through the European Regional Development Fund (ERDF) [NORTE-07-0124-FEDER-000058]; national funds, through the Portuguese funding agency, FCT

Available from: 2016-12-30 Created: 2016-12-29 Last updated: 2017-11-29

Open Access in DiVA

fulltext(6198 kB)29 downloads
File information
File name FULLTEXT01.pdfFile size 6198 kBChecksum SHA-512
f9e6d922bc9c677d6374ea72a5ad4289cbd80f78cf87227913b45ebf3c1f7eb95326084d108318fbcb2949b2959c37601f8b161e74da3c217e67644761b5b6de
Type fulltextMimetype application/pdf

Other links

Publisher's full text

Search in DiVA

By author/editor
Bernacka-Wojcik, Iwona
By organisation
Physics and ElectronicsFaculty of Science & Engineering
In the same journal
Micromachines
Other Medical Engineering

Search outside of DiVA

GoogleGoogle Scholar
Total: 29 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

doi
urn-nbn

Altmetric score

doi
urn-nbn
Total: 32 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf