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Lipooligosaccharide locus classes and putative virulence genes among chicken and human Campylobacter jejuni isolates
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Clinical Microbiology and Infectious Medicine, Clinical Bacteriology. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology.
Natl Vet Inst, EU Reference Lab Campylobacter, Dept Microbiol, SE-75189 Uppsala, Sweden..
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Clinical Microbiology and Infectious Medicine, Clinical Bacteriology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Clinical Microbiology and Infectious Medicine, Clinical Bacteriology. Univ Helsinki, Dept Bacteriol & Immunol, POB 21, FIN-00014 Helsinki, Finland..
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2016 (English)In: BMC Microbiology, ISSN 1471-2180, E-ISSN 1471-2180, Vol. 16, article id 116Article in journal (Refereed) Published
Abstract [en]

Background: Campylobacter cause morbidity and considerable economic loss due to hospitalization and post infectious sequelae such as reactive arthritis, Guillain Barr-and Miller Fischer syndromes. Such sequelae have been linked to C. jejuni harboring sialic acid structures in their lipooligosaccharide (LOS) layer of the cell wall. Poultry is an important source of human Campylobacter infections but little is known about the prevalence of sialylated C. jejuni isolates and the extent of transmission of such isolates to humans. Results: Genotypes of C. jejuni isolates from enteritis patients were compared with those of broiler chicken with pulsed-field gel electrophoresis (PFGE), to study the patterns of LOS biosynthesis genes and other virulence associated genes and to what extent these occur among Campylobacter genotypes found both in humans and chickens. Chicken and human isolates generally had similar distributions of the putative virulence genes and LOS locus classes studied. However, there were significant differences regarding LOS locus class of PFGE types that were overlapping between chicken and human isolates and those that were distinct to each source. Conclusions: The study highlights the prevalence of virulence associated genes among Campylobacter isolates from humans and chickens and suggests possible patterns of transmission between the two species.

Place, publisher, year, edition, pages
2016. Vol. 16, article id 116
Keywords [en]
Campylobacter, LOS, Pulsed Field Gel Electrophoresis (PFGE), Virulence genes, Transmission
National Category
Microbiology in the medical area
Identifiers
URN: urn:nbn:se:uu:diva-311508DOI: 10.1186/s12866-016-0740-5ISI: 000388909800001PubMedID: 27871232OAI: oai:DiVA.org:uu-311508DiVA, id: diva2:1060387
Funder
Swedish Research Council, 521-2011-3527Swedish Research Council Formas, 221-2012-1442Available from: 2016-12-28 Created: 2016-12-28 Last updated: 2018-01-13Bibliographically approved

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