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Photopatterning of hyaluronic acid hydrogels for cell culture scaffolds
Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Microsystems Technology. (EMBLA)ORCID iD: 0000-0001-5952-2418
Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Microsystems Technology. (EMBLA)ORCID iD: 0000-0002-9790-780X
Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - Ångström, Polymer Chemistry.
Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - Ångström, Polymer Chemistry.ORCID iD: 0000-0002-0323-4799
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2016 (English)Conference paper, Poster (with or without abstract) (Refereed)
Abstract [en]

Organs-on-chips technologies require the development of micro engineered devices to represent functional units of human organs. These devices use cell culture scaffolds to give support and structure for the cultured cells. Hydrogels are attractive scaffold materials, due to their high water content and because they are derived from natural polymers found in the extracellular matrix of different tissues in the human body. Hyaluronic acid can form hydrogels when functionalized with chemo-selective groups. These chemically cross-linked hydrogels can be modified with adhesion motifs, such as RGD peptides, to increase their biocompatibility and promote cell adhesion. In this work we use a photolithographic method to pattern the RGD peptide into distinct areas of the hyaluronic acid hydrogel with the aim to spatially control the cell attachment on the HA hydrogel scaffolds

Place, publisher, year, edition, pages
2016.
National Category
Engineering and Technology
Research subject
Engineering Science with specialization in Microsystems Technology
Identifiers
URN: urn:nbn:se:uu:diva-310457OAI: oai:DiVA.org:uu-310457DiVA, id: diva2:1058734
Conference
27th Micromechanics and Microsystems Europe workshop (MME 2016), Cork, Ireland, August 28-30 2016
Available from: 2016-12-21 Created: 2016-12-16 Last updated: 2017-01-04Bibliographically approved

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fulltext(3099 kB)228 downloads
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