Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Neurosensory Differentiation and Innervation Patterning in the Human Fetal Vestibular End Organs between the Gestational Weeks 8-12
Med Univ Innsbruck, Dept Otolaryngol, Innsbruck, Austria..ORCID iD: 0000-0002-2528-1449
Med Univ Innsbruck, Div Clin & Funct Anat, Dept Anat Histol & Embryol, Innsbruck, Austria..
Med Univ Innsbruck, Div Clin & Funct Anat, Dept Anat Histol & Embryol, Innsbruck, Austria..
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Otolaryngology and Head and Neck Surgery.
Show others and affiliations
2016 (English)In: Frontiers in Neuroanatomy, ISSN 1662-5129, E-ISSN 1662-5129, Vol. 10, article id 111Article in journal (Refereed) Published
Abstract [en]

Balance orientation depends on the precise operation of the vestibular end organs and the vestibular ganglion neurons. Previous research on the assemblage of the neuronal network in the developing fetal vestibular organ has been limited to data from animal models. Insights into the molecular expression profiles and signaling moieties involved in embryological development of the human fetal inner ear have been limited. We present an investigation of the cells of the vestibular end organs with specific focus on the hair cell differentiation and innervation pattern using an uninterrupted series of unique specimens from gestational weeks 8-12. Nerve fibers positive for peripherin innervate the entire fetal crista and utricle. While in rodents only the peripheral regions of the cristae and the extra-striolar region of the statolithic organs are stained. At week 9, transcription factors PAX2 and PAX8 were observed in the hair cells whereas PAX6 was observed for the first time among the supporting cells of the cristae and the satellite glial cells of the vestibular ganglia. Glutamine synthetase, a regulator of the neurotransmitter glutamate, is strongly expressed among satellite glia cells, transitional zones of the utricle and supporting cells in the sensory epithelium. At gestational week 11, electron microscopic examination reveals bouton contacts at hair cells and first signs of the formation of a protocalyx at type I hair cells. Our study provides first-hand insight into the fetal development of the vestibular end organs as well as their pattern of innervation by means of immunohistochemical and EM techniques, with the aim of contributing toward our understanding of balance development.

Place, publisher, year, edition, pages
2016. Vol. 10, article id 111
Keywords [en]
inner ear, vestibulum, human, transcription factors, PAX2, PAX6, PAX8, MAF B
National Category
Neurology
Identifiers
URN: urn:nbn:se:uu:diva-310748DOI: 10.3389/fnana.2016.00111ISI: 000387539500001OAI: oai:DiVA.org:uu-310748DiVA, id: diva2:1058156
Funder
EU, European Research Council, 603029Available from: 2016-12-20 Created: 2016-12-19 Last updated: 2017-11-29Bibliographically approved

Open Access in DiVA

fulltext(10499 kB)103 downloads
File information
File name FULLTEXT01.pdfFile size 10499 kBChecksum SHA-512
132283d0f4ba97cb600a32767745d5c2ee0f5a5591513528d6460d8da3cf04af4ac8e232925fafb5869cf334d75080b4a6c4f27ff98d9ca1d06298cece0ae2a1
Type fulltextMimetype application/pdf

Other links

Publisher's full text

Search in DiVA

By author/editor
Johnson Chacko, LejoRask-Andersen, Helge
By organisation
Otolaryngology and Head and Neck Surgery
In the same journal
Frontiers in Neuroanatomy
Neurology

Search outside of DiVA

GoogleGoogle Scholar
Total: 103 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

doi
urn-nbn

Altmetric score

doi
urn-nbn
Total: 522 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf