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Staphylococcus capitis isolated from prosthetic joint infections
Karlstad Hospital, Karlstad, Sweden; Örebro University, Örebro, Sweden.
Faculty of Medicine and Health, Örebro University, Örebro, Sweden.
Region Östergötland, Heart and Medicine Center, Department of Infectious Diseases. Linköping University, Department of Clinical and Experimental Medicine, Division of Microbiology and Molecular Medicine. Linköping University, Faculty of Medicine and Health Sciences.
Faculty of Medicine and Health, Örebro University, Örebro, Sweden.
2017 (English)In: European Journal of Clinical Microbiology and Infectious Diseases, ISSN 0934-9723, E-ISSN 1435-4373, Vol. 36, no 1, p. 115-122Article in journal (Refereed) Published
Abstract [en]

Further knowledge about the clinical and microbiological characteristics of prosthetic joint infections (PJIs) caused by different coagulase-negative staphylococci (CoNS) may facilitate interpretation of microbiological findings and improve treatment algorithms. Staphylococcus capitis is a CoNS with documented potential for both human disease and nosocomial spread. As data on orthopaedic infections are scarce, our aim was to describe the clinical and microbiological characteristics of PJIs caused by S. capitis. This retrospective cohort study included three centres and 21 patients with significant growth of S. capitis during revision surgery for PJI between 2005 and 2014. Clinical data were extracted and further microbiological characterisation of the S. capitis isolates was performed. Multidrug-resistant (≥3 antibiotic groups) S. capitis was detected in 28.6 % of isolates, methicillin resistance in 38.1 % and fluoroquinolone resistance in 14.3 %; no isolates were rifampin-resistant. Heterogeneous glycopeptide-intermediate resistance was detected in 38.1 %. Biofilm-forming ability was common. All episodes were either early post-interventional or chronic, and there were no haematogenous infections. Ten patients experienced monomicrobial infections. Among patients available for evaluation, 86 % of chronic infections and 70 % of early post-interventional infections achieved clinical cure; 90 % of monomicrobial infections remained infection-free. Genetic fingerprinting with repetitive sequence-based polymerase chain reaction (rep-PCR; DiversiLab®) displayed clustering of isolates, suggesting that nosocomial spread might be present. Staphylococcus capitis has the potential to cause PJIs, with infection most likely being contracted during surgery or in the early postoperative period. As S. capitis might be an emerging nosocomial pathogen, surveillance of the prevalence of PJIs caused by S. capitis could be recommended.

Place, publisher, year, edition, pages
Springer, 2017. Vol. 36, no 1, p. 115-122
National Category
Infectious Medicine
Identifiers
URN: urn:nbn:se:liu:diva-133307DOI: 10.1007/s10096-016-2777-7ISI: 000391388800014OAI: oai:DiVA.org:liu-133307DiVA, id: diva2:1057647
Note

Funding agencies: research committee of Varmland County Council, Sweden [LIVFOU-456821, LIVFOU-457061]; research committee of Ostergotland County Council, Sweden [LIO-447091]; Orebro University, Sweden [ORU 1.3.1-01273/2015]

Available from: 2016-12-19 Created: 2016-12-19 Last updated: 2017-11-29

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