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Impact of comorbidity on risk of venous thromboembolism in patients with breast cancer: a Danish population-based cohort study
Aarhus Univ Hosp, Dept Clin Epidemiol, DK-8000 Aarhus, Denmark..
Aarhus Univ Hosp, Dept Clin Epidemiol, DK-8000 Aarhus, Denmark..
Aalborg Univ Hosp, Breast Clin, Aalborg, Denmark..
Univ Uppsala Hosp, Dept Oncol, S-75185 Uppsala, Sweden..
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2014 (English)In: BMJ Open, ISSN 2044-6055, E-ISSN 2044-6055, Vol. 4, no 6, article id e005082Article in journal (Refereed) Published
Abstract [en]

Objectives: To assess the interaction between comorbidity and breast cancer (BC) on the rate of venous thromboembolism (VTE) beyond what can be explained by the independent effects of BC and comorbidity. Design: Population-based matched cohort study. Setting: Denmark. Participants: Danish patients with BC (n=62 376) diagnosed in 1995-2010 and a comparison cohort of women without BC (n=304 803) from the general population were matched to the patients with BC on year of birth in 5-year intervals and on the specific diseases included in the Charlson Comorbidity Index (CCI) and atrial fibrillation and obesity. Measures: The rate ratios of VTE per 1000 person-years (PY) were computed by comorbidity levels using the CCI, and interaction contrasts (IC) were calculated as a measure of the excess or deficit VTE rate not explained by the independent effects of BC and comorbidity. Results: Among patients with BC with a CCI score of 1, the 0-1 year VTE rate was 12/1000 PY, and interaction accounted for 10% of the rate (IC=3.2, 95% CI 0.5 to 5.9). Among patients with BC with CCI >= 4, the VTE rate was 17, and interaction accounted for 8% of the rate (IC=1.2, 95% CI -1.8 to 4.2). There was no interaction during 2-5 years of follow-up. Conclusions: There was only little interaction between BC and the CCI score on the rate of VTE.

Place, publisher, year, edition, pages
2014. Vol. 4, no 6, article id e005082
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Cancer and Oncology
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URN: urn:nbn:se:uu:diva-310546DOI: 10.1136/bmjopen-2014-005082ISI: 000339717100068PubMedID: 24902734OAI: oai:DiVA.org:uu-310546DiVA, id: diva2:1057528
Available from: 2016-12-19 Created: 2016-12-16 Last updated: 2017-11-29Bibliographically approved

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Nyström, Petra WittVyberg, Mogens
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