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Loss of NMDA receptors in dopamine neurons leads to the development of affective disorder-like symptoms in mice
Polish Academic Science, Poland.
Jagiellonian University, Poland.
Polish Academic Science, Poland.
Polish Academic Science, Poland.
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2016 (English)In: Scientific Reports, ISSN 2045-2322, E-ISSN 2045-2322, Vol. 6, article id 37171Article in journal (Refereed) Published
Abstract [en]

The role of changes in dopamine neuronal activity during the development of symptoms in affective disorders remains controversial. Here, we show that inactivation of NMDA receptors on dopaminergic neurons in adult mice led to the development of affective disorder-like symptoms. The loss of NMDA receptors altered activity and caused complete NMDA-insensitivity in dopamine-like neurons. Mutant mice exhibited increased immobility in the forced swim test and a decrease in social interactions. Mutation also led to reduced saccharin intake, however the preference of sweet taste was not significantly decreased. Additionally, we found that while mutant mice were slower to learn instrumental tasks, they were able to reach the same performance levels, had normal sensitivity to feedback and showed similar motivation to exert effort as control animals. Taken together these results show that inducing the loss of NMDA receptor-dependent activity in dopamine neurons is associated with development of affective disorder-like symptoms.

Place, publisher, year, edition, pages
NATURE PUBLISHING GROUP , 2016. Vol. 6, article id 37171
National Category
Neurosciences
Identifiers
URN: urn:nbn:se:liu:diva-133263DOI: 10.1038/srep37171ISI: 000388232700001PubMedID: 27853270OAI: oai:DiVA.org:liu-133263DiVA, id: diva2:1057484
Note

Funding Agencies|Polish National Science Centre [HARMONIA 2012/06/M/NZ4/00143]; KNOW program - Polish Ministry of Science and Higher Education

Available from: 2016-12-18 Created: 2016-12-15 Last updated: 2018-01-13

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