Change search
ReferencesLink to record
Permanent link

Direct link
Physical Activity, Blood Glucose and C-Peptide in Healthy School-Children, a Longitudinal Study
Jönköping University, School of Health and Welfare, HHJ, Dep. of Nursing Science. Jönköping University, School of Health and Welfare, HHJ. CHILD.ORCID iD: 0000-0003-4599-155X
Linköping University, Sweden.
Linnaeus University and University of Gothenburg, Sweden.
Linköping University and Östergötland County Council, Sweden.
2016 (English)In: PLoS ONE, ISSN 1932-6203, E-ISSN 1932-6203, Vol. 11, no 6, e0156401Article in journal (Refereed) Published
Abstract [en]

Aim

To further elucidate the relationship between physical activity and several risk factors for development of diabetes (glucose, C-peptide and obesity) over time.

Methods

A prospective longitudinal study where physical activity was measured on 199 children from Kalmar and Linköping at age 8, and the same 107 children from Linköping again at age 12. Anthropometric data was collected and blood was analyzed for C-peptide and f-glucose. The children in the study were representative for the general Swedish child population, and on an average lean.

Results

High physical activity was related to lower C-peptide at age 8 and 12. This correlation was especially pronounced in boys, who also were more physically active than girls at both time points. The association seen at 8 years of age was similar at age 12 in most children. Children with higher BMI Z-Score had a higher fasting C-peptide (age 12) but linear regression showed that children with more steps per day were less likely to have a higher fasting C-peptide irrespective of BMI. Longitudinal follow-up showed that a decrease in physical activity increased insulin resistance and β-cell load.

Conclusions

Already in young children, physical activity improves insulin sensitivity and decreases the need of C-peptide over time. This seems to become even more pronounced with increasing age when children are followed longitudinally. Low physical activity increases the load on insulin producing β-cells, might increase the risk for both type 1- and 2 diabetes.

Place, publisher, year, edition, pages
2016. Vol. 11, no 6, e0156401
National Category
Pediatrics
Identifiers
URN: urn:nbn:se:hj:diva-34138DOI: 10.1371/journal.pone.0156401ISI: 000377561000012PubMedID: 27270732ScopusID: 2-s2.0-84975221785OAI: oai:DiVA.org:hj-34138DiVA: diva2:1051016
Available from: 2016-11-30 Created: 2016-11-30 Last updated: 2016-11-30Bibliographically approved

Open Access in DiVA

fulltext(473 kB)5 downloads
File information
File name FULLTEXT01.pdfFile size 473 kBChecksum SHA-512
d65de81bab33853bd564fbf2577fd8bd5a6cf7db51328747898ae15b12309a8845c6201c4a7151f210f27d4f9ffcfed9e217fce1cc79d85668ee3777e79eef3c
Type fulltextMimetype application/pdf

Other links

Publisher's full textPubMedScopus

Search in DiVA

By author/editor
Huus, Karina
By organisation
HHJ, Dep. of Nursing ScienceHHJ. CHILD
In the same journal
PLoS ONE
Pediatrics

Search outside of DiVA

GoogleGoogle Scholar
Total: 5 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 40 hits
ReferencesLink to record
Permanent link

Direct link