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Throat Infections are Associated with Exacerbation in a Substantial Proportion of Patients with Chronic Plaque Psoriasis
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Dermatology and Venereology. Univ Iceland, Dermatol Sect, Fac Med, Reykjavik, Iceland.;Landspitali Natl Univ Hosp Iceland, Dept Immunol, Reykjavik, Iceland..
Univ Iceland, Dermatol Sect, Fac Med, Reykjavik, Iceland.;Landspitali Natl Univ Hosp Iceland, Dept Immunol, Reykjavik, Iceland..
Univ Iceland, Dermatol Sect, Fac Med, Reykjavik, Iceland..
Landspitali Natl Univ Hosp Iceland, Dept Med, Reykjavik, Iceland..
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2016 (English)In: Acta Dermato-Venereologica, ISSN 0001-5555, E-ISSN 1651-2057, Vol. 96, no 6, 788-791 p.Article in journal (Refereed) Published
Abstract [en]

Streptococcal throat infections are known to trigger or exacerbate psoriasis, and several studies support the benefit of tonsillectomy. To evaluate the potential of tonsillectomy as a treatment, we used a retrospective study-specific questionnaire to assess the proportion of psoriasis patients with sore throat-associated psoriasis exacerbations. Our survey sampled 275 psoriasis patients. Of patients with plaque psoriasis, 42% reported sore throat-associated psoriasis exacerbations, and of patients with confirmed streptococcal infections, 72% reported aggravation. Notably, women and patients with early onset psoriasis were more likely to report psoriasis exacerbation after a sore throat (p< 0.001, p = 0.046, respectively). Other psoriasis aggravation factors were more common in patients with sore throat-associated exacerbations (p < 0.01). Of tonsillectomized patients, 49% reported subsequent improvement and had more frequent sore throat -associated aggravation of psoriasis than patients who did not improve after tonsillectomy (p=0.015). These findings suggest a closer association between sore throats, streptococcal throat infections and plaque psoriasis than reported previously.

Place, publisher, year, edition, pages
2016. Vol. 96, no 6, 788-791 p.
Keyword [en]
chronic plaque psoriasis, sore throat, streptococcal throat infections, tonsillectomy
National Category
Dermatology and Venereal Diseases
Identifiers
URN: urn:nbn:se:uu:diva-308372DOI: 10.2340/00015555-2408ISI: 000383216700014PubMedID: 26984718OAI: oai:DiVA.org:uu-308372DiVA: diva2:1049670
Funder
NIH (National Institute of Health), K01 AR064765
Available from: 2016-11-25 Created: 2016-11-25 Last updated: 2016-11-25Bibliographically approved

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