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Evidence for the Introduction, Reassortment, and Persistence of Diverse Influenza A Viruses in Antarctica
WHO, Collaborating Ctr Reference & Res Influenza, Parkville, Vic, Australia.;Univ Melbourne, Melbourne Sch Populat & Global Hlth, Parkville, Vic, Australia..
Duke NUS Med Sch, Program Emerging Infect Dis, Singapore, Singapore..
WHO, Collaborating Ctr Reference & Res Influenza, Parkville, Vic, Australia..
WHO, Collaborating Ctr Reference & Res Influenza, Parkville, Vic, Australia..
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2016 (English)In: Journal of Virology, ISSN 0022-538X, E-ISSN 1098-5514, Vol. 90, no 21, 9674-9682 p.Article in journal (Refereed) Published
Abstract [en]

Avian influenza virus (AIV) surveillance in Antarctica during 2013 revealed the prevalence of evolutionarily distinct influenza viruses of the H11N2 subtype in Adelie penguins. Here we present results from the continued surveillance of AIV on the Antarctic Peninsula during 2014 and 2015. In addition to the continued detection of H11 subtype viruses in a snowy sheathbill during 2014, we isolated a novel H5N5 subtype virus from a chinstrap penguin during 2015. Gene sequencing and phylogenetic analysis revealed that the H11 virus detected in 2014 had a >99.1% nucleotide similarity to the H11N2 viruses isolated in 2013, suggesting the continued prevalence of this virus in Antarctica over multiple years. However, phylogenetic analysis of the H5N5 virus showed that the genome segments were recently introduced to the continent, except for the NP gene, which was similar to that in the endemic H11N2 viruses. Our analysis indicates geographically diverse origins for the H5N5 virus genes, with the majority of its genome segments derived from North American lineage viruses but the neuraminidase gene derived from a Eurasian lineage virus. In summary, we show the persistence of AIV lineages in Antarctica over multiple years, the recent introduction of gene segments from diverse regions, and reassortment between different AIV lineages in Antarctica, which together significantly increase our understanding of AIV ecology in this fragile and pristine environment.

Place, publisher, year, edition, pages
2016. Vol. 90, no 21, 9674-9682 p.
National Category
Infectious Medicine
Identifiers
URN: urn:nbn:se:uu:diva-307521DOI: 10.1128/JVI.01404-16ISI: 000385525700011PubMedID: 27535050OAI: oai:DiVA.org:uu-307521DiVA: diva2:1048211
Funder
NIH (National Institute of Health), HHSN272201400006C
Available from: 2016-11-21 Created: 2016-11-17 Last updated: 2016-11-21Bibliographically approved

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Ellström, PatrikHernandez, JorgeOlsen, Björn
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Department of Medical Biochemistry and MicrobiologyInfection medicine
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