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Evaluation of Biocompatibility and Release of Reactive Oxygen Species of Aluminum Oxide-Coated Materials
Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Microsystems Technology.ORCID iD: 0000-0001-7462-4236
Department of Engineering Sciences and Metallurgy, Technical University of Catalonia, Diagonal 647, 08028 Barcelona, Spain.
Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Applied Materials Sciences.
Uppsala University, Science for Life Laboratory, SciLifeLab. Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Microsystems Technology. Department of Biomedical Engineering, Lund University, Box 118, 221 00 Lund, Sweden.ORCID iD: 0000-0002-1264-1337
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2016 (English)In: ACS Omega, ISSN 2470-1343, Vol. 1, no 4, 706-713 p.Article in journal (Refereed) Published
Abstract [en]

Surface properties of biomaterials can strongly influence biomaterial−host interactions. For this reason, coating processes open a wide range of possibilities to modulate the fate of a biomaterial in the body. This study evaluates the effect of a coating material intended for drug delivery capsules on biocompatibility and the release of reactive oxygen species (ROS), that is, respiratory burst in macrophages that indicates acute inflammation. In parallel with a new approach to develop drug-delivery capsules by directly coating solid-state drug particles, in this study, glass slides and silicon nanoparticles (NPs) were coated with aluminum oxide (Al2O3) using atomic layer deposition. Different sizes of NPs (20 and 310 nm) were suspended at different concentrations (10, 100, and 1000 μg/mL) and were evaluated. The homogeneous coating of slides was proved using X-ray photoelectron spectroscopy, and the coating on NP was observed using transmission electron microscopy. Human dermal fibroblasts and human osteoblasts were able to proliferate on the coated slides and in the presence of a suspension of coated NPs (20 and 310 nm) at a low concentration (10 μg/mL). The macrophages released ROS only when in contact with NPs at a concentration of 1000 μg/mL, where the 20 nm NPs caused a higher release of ROS than the 310 nm NPs. This study shows that Al2O3 coatings do not affect the cells negatively and that the cell viability was compromised only when in contact with a high concentration (1000 μg/mL) of smaller (20 nm) NPs. 

Place, publisher, year, edition, pages
2016. Vol. 1, no 4, 706-713 p.
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Materials Engineering
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URN: urn:nbn:se:uu:diva-307254DOI: 10.1021/acsomega.6b00198OAI: oai:DiVA.org:uu-307254DiVA: diva2:1045971
Available from: 2016-11-11 Created: 2016-11-11 Last updated: 2016-11-16Bibliographically approved

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Mestres, GemmaXia, WeiTenje, MariaOtt, Marjam
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