Change search
ReferencesLink to record
Permanent link

Direct link
High Maternal Body Mass Index in Early Pregnancy and Risks of Stillbirth and Infant Mortality-A Population-Based Sibling Study in Sweden
Karolinska Inst, Stockholm, Sweden..
Karolinska Inst, Stockholm, Sweden.;Karolinska Inst, Soder Sjukhuset, Dept Clin Sci & Educ, Stockholm, Sweden..
Karolinska Inst, Stockholm, Sweden.;Univ Calif Berkeley, Sch Publ Hlth, Div Epidemiol, Berkeley, CA 94720 USA..
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, Obstetrics and Gynaecology. Karolinska Inst, Stockholm, Sweden..
Show others and affiliations
2016 (English)In: American Journal of Epidemiology, ISSN 0002-9262, E-ISSN 1476-6256, Vol. 184, no 2, 98-105 p.Article in journal (Refereed) Published
Abstract [en]

In a population-based case-control study, we investigated whether familial confounding influenced the associations between maternal overweight/obesity and risks of stillbirth and infant mortality by including both population and sister controls. Using nationwide data from the Swedish Medical Birth Register (1992-2011), we included all primiparous women with singleton births who also had a sister with a first birth during that time period. We used logistic regression analyses to calculate odds ratios (and 95% confidence intervals) adjusted for maternal age, height, smoking habits, education, and time period (5-year groups) of child's birth. Body mass index (BMI) was calculated as weight (kg)/height (m)(2). Compared with population controls with a normal BMI (18.5-24.9), stillbirth risk increased with increasing BMI (BMI 25-29.9: odds ratio (OR) = 1.51 (95% confidence interval (CI): 1.21, 1.89); BMI 30-34.9: OR = 1.77 (95% CI: 1.24, 2.50); BMI a parts per thousand yen35: OR = 3.16 (95% CI: 2.10, 4.76)). The sister case-control analyses revealed similar results. Offspring of obese women (BMI a parts per thousand yen30) had an increased risk of infant mortality when population controls were used (OR = 2.41, 95% CI: 1.83, 3.16), and an even higher risk was obtained when sister controls were used (OR = 4.04, 95% CI: 2.25, 7.25). We conclude that obesity in early pregnancy is associated with increased risks of stillbirth and infant mortality independently of genetic and early environmental risk factors shared within families.

Place, publisher, year, edition, pages
2016. Vol. 184, no 2, 98-105 p.
Keyword [en]
body mass index, familial confounding, infant mortality, neonatal mortality, postneonatal mortality, sibling-design studies, stillbirth
National Category
Public Health, Global Health, Social Medicine and Epidemiology
Identifiers
URN: urn:nbn:se:uu:diva-305945DOI: 10.1093/aje/kww046ISI: 000383101500002PubMedID: 27358265OAI: oai:DiVA.org:uu-305945DiVA: diva2:1044530
Funder
Forte, Swedish Research Council for Health, Working Life and Welfare
Available from: 2016-11-03 Created: 2016-10-24 Last updated: 2016-11-03Bibliographically approved

Open Access in DiVA

fulltext(276 kB)13 downloads
File information
File name FULLTEXT01.pdfFile size 276 kBChecksum SHA-512
0cf83578a95d2db105c048713f52142cc312162efc4b53f80a2e056ffd029f01533aa81c21b785b5d035a25ca0b6af569bf34c5336eb8a91aee9647d44c68a05
Type fulltextMimetype application/pdf

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Wikström, Anna-Karin
By organisation
Obstetrics and Gynaecology
In the same journal
American Journal of Epidemiology
Public Health, Global Health, Social Medicine and Epidemiology

Search outside of DiVA

GoogleGoogle Scholar
Total: 13 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 41 hits
ReferencesLink to record
Permanent link

Direct link