Change search
ReferencesLink to record
Permanent link

Direct link
Factors associated with experience of fatigue, and functional limitations due to fatigue in patients with stable COPD
Linköping University, Department of Medical and Health Sciences. Linköping University, Faculty of Medicine and Health Sciences. Ryhov County Hospital, Sweden.
Linköping University, Department of Medical and Health Sciences. Linköping University, Faculty of Medicine and Health Sciences. Skåne University Hospital, Sweden.
Linköping University, Department of Medical and Health Sciences. Linköping University, Faculty of Medicine and Health Sciences.
Ryhov County Hospital, Sweden.
Show others and affiliations
2016 (English)In: THERAPEUTIC ADVANCES IN RESPIRATORY DISEASE, ISSN 1753-4658, Vol. 10, no 5, 410-424 p.Article in journal (Refereed) Published
Abstract [en]

Background: The aim of this study was to determine the influence of selected physiological, psychological and situational factors on experience of fatigue, and functional limitations due to fatigue in patients with stable chronic obstructive pulmonary disease (COPD). Methods: In total 101 patients with COPD and 34 control patients were assessed for experience of fatigue, functional limitation due to fatigue (Fatigue Impact Scale), physiological [lung function, 6-minute walk distance (6MWD), body mass index (BMI), dyspnoea, interleukin (IL)-6, IL-8, high sensitivity C-reactive protein (hs-CRP), surfactant protein D], psychological (anxiety, depression, insomnia), situational variables (age, sex, smoking, living alone, education), and quality of life. Results: Fatigue was more common in patients with COPD than in control patients (72% versus 56%, p amp;lt; 0.001). Patients with COPD and fatigue had lower lung function, shorter 6MWD, more dyspnoea, anxiety and depressive symptoms, and worse health status compared with patients without fatigue (all p amp;lt; 0.01). No differences were found for markers of systemic inflammation. In logistic regression, experience of fatigue was associated with depression [odds ratio (OR) 1.69, 95% confidence interval (CI) 1.28-2.25) and insomnia (OR 1.75, 95% CI 1.19-2.54). In linear regression models, depression, surfactant protein D and dyspnoea explained 35% (R-2) of the variation in physical impact of fatigue. Current smoking and depression explained 33% (R-2) of the cognitive impact of fatigue. Depression and surfactant protein D explained 48% (R-2) of the psychosocial impact of fatigue. Conclusions: Experiences of fatigue and functional limitation due to fatigue seem to be related mainly to psychological but also to physiological influencing factors, with depressive symptoms, insomnia problems and dyspnoea as the most prominent factors. Systemic inflammation was not associated with perception of fatigue but surfactant protein D was connected to some dimensions of the impact of fatigue

Place, publisher, year, edition, pages
SAGE PUBLICATIONS LTD , 2016. Vol. 10, no 5, 410-424 p.
Keyword [en]
chronic obstructive pulmonary disease; fatigue; symptoms; systemic inflammation
National Category
Respiratory Medicine and Allergy
Identifiers
URN: urn:nbn:se:liu:diva-132209DOI: 10.1177/1753465816661930ISI: 000384456300004PubMedID: 27591046OAI: oai:DiVA.org:liu-132209DiVA: diva2:1043946
Note

Funding Agencies|Swedish Heart Lung Foundation; Medical Research Council of Southeast Sweden; County Council of Ostergotland; County Council of Jonkoping (Futurum)

Available from: 2016-11-01 Created: 2016-10-21 Last updated: 2016-11-21

Open Access in DiVA

fulltext(618 kB)13 downloads
File information
File name FULLTEXT01.pdfFile size 618 kBChecksum SHA-512
709853a617e75e815baf6baff64afea9283a612794484f9ff190e335d8ab0b28735f3bf56a114c7ca713acf9f9891cb690509de6c87509b55574eb88bcd843a7
Type fulltextMimetype application/pdf

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Kentson, MagnusTödt, KristinaSkargren, ElisabethErnerudh, JanUnosson, Mitra
By organisation
Department of Medical and Health SciencesFaculty of Medicine and Health SciencesDivision of Neuro and Inflammation ScienceDepartment of Clinical Immunology and Transfusion MedicineDivision of Nursing Science
Respiratory Medicine and Allergy

Search outside of DiVA

GoogleGoogle Scholar
Total: 13 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 17 hits
ReferencesLink to record
Permanent link

Direct link