Change search
ReferencesLink to record
Permanent link

Direct link
Cerebral microbleeds in idiopathic normal pressure hydrocephalus
Umeå University, Faculty of Medicine, Department of Pharmacology and Clinical Neuroscience.
Umeå University, Faculty of Medicine, Department of Radiation Sciences. Umeå University, Faculty of Science and Technology, Centre for Biomedical Engineering and Physics (CMTF).
Umeå University, Faculty of Medicine, Department of Radiation Sciences.
Umeå University, Faculty of Medicine, Department of Radiation Sciences.
Show others and affiliations
2016 (English)In: Fluids and Barriers of the CNS, ISSN 2045-8118, E-ISSN 2045-8118, Vol. 13, UNSP 4Article in journal (Refereed) Published
Abstract [en]

Background: A vascular disease could be involved in pathophysiology of normal pressure hydrocephalus (INPH). If so, there should be an association between INPH and cerebral microbleeds (CMB). This study aims to analyze if CMB are associated with INPH.

Methods: In this case-control study we included 14 patients with INPH (mean age 76 years, 60 % female) and 41 healthy controls (HeCo; mean age 71 years, 60 % female). All were investigated with magnetic resonance imaging (MRI) using a T2*-sequence. The MRI exams were reviewed by two neuroradiologists for the presence of CMBs; the prevalence of findings of two or more CMBs was compared between INPH group and control group. After investigation, INPH patients underwent shunt surgery.

Results: Two or more CMB were detected more frequently in the INPH group compared to HeCo (n = 6, 43 % vs. n = 4, 10 %; p = 0.01). Among the participants where MRI revealed CMB, the number of CMB was higher among the INPH patients than the HeCo (median 8; IQR 2-34 vs. median 1; IQR 1-2; p = 0.005).

Conclusions: This study supports a vascular component to the pathophysiology of INPH.

Place, publisher, year, edition, pages
2016. Vol. 13, UNSP 4
Keyword [en]
Idiopathic normal pressure hydrocephalus, Magnetic resonance imaging, Cerebral microbleeds
National Category
Neurology
Identifiers
URN: urn:nbn:se:umu:diva-126799DOI: 10.1186/s12987-016-0028-zISI: 000381859400001PubMedID: 26860218OAI: oai:DiVA.org:umu-126799DiVA: diva2:1043826
Available from: 2016-11-01 Created: 2016-10-14 Last updated: 2016-11-01Bibliographically approved

Open Access in DiVA

fulltext(823 kB)12 downloads
File information
File name FULLTEXT01.pdfFile size 823 kBChecksum SHA-512
eefb099edcdfb4cea46db8805e474d982a0a9be5cea271f82714665ac13c5c2f8d373df005c8951f2eb0098e91d066f1459f4a861bed1f227558086c18e300a2
Type fulltextMimetype application/pdf

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Johansson, EliasAmbarki, KhalidBirgander, RichardBahrami, NazilaEklund, AndersMalm, Jan
By organisation
Department of Pharmacology and Clinical NeuroscienceDepartment of Radiation SciencesCentre for Biomedical Engineering and Physics (CMTF)
In the same journal
Fluids and Barriers of the CNS
Neurology

Search outside of DiVA

GoogleGoogle Scholar
Total: 12 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 47 hits
ReferencesLink to record
Permanent link

Direct link