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Systematic review of loperamide: No proof of antibiotics being superior to loperamide in treatment of mild/moderate travellers' diarrhoea
Univ Helsinki, Div Infect Dis, Inflammat Ctr, POB 348, FIN-00029 Helsinki, Hus, Finland.;Helsinki Univ Hosp, POB 348, FIN-00029 Helsinki, Hus, Finland..
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Centrum för klinisk forskning i Sörmland (CKFD). Sormland Cty Council, Clin Res Ctr, Eskilstuna, Sweden..
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Centrum för klinisk forskning i Sörmland (CKFD). Sormland Cty Council, Clin Res Ctr, Eskilstuna, Sweden.;Karolinska Inst, Dept Med Solna, Infect Dis Unit, SE-17176 Stockholm, Sweden..
Univ Helsinki, Div Infect Dis, Inflammat Ctr, POB 348, FIN-00029 Helsinki, Hus, Finland.;Helsinki Univ Hosp, POB 348, FIN-00029 Helsinki, Hus, Finland.;Karolinska Inst, Dept Med Solna, Infect Dis Unit, SE-17176 Stockholm, Sweden.;Univ Helsinki, Dept Med, FIN-00029 Helsinki, Hus, Finland..
2016 (English)In: Travel Medicine and Infectious Disease, ISSN 1477-8939, E-ISSN 1873-0442, Vol. 14, no 4, 299-312 p.Article, review/survey (Refereed) Published
Abstract [en]

Looking at the worldwide emergency of antimicrobial resistance, international travellers appear to have a central role in spreading the bacteria across the globe. Travellers' diarrhoea (TD) is the most common disease encountered by visitors to the (sub) tropics. Both TD and its treatment with antibiotics have proved significant independent risk factors of colonization by resistant intestinal bacteria while travelling. Travellers should therefore be given preventive advice regarding TD and cautioned about taking antibiotics: mild or moderate TD does not require antibiotics. Logical alternatives are medications with effects on gastrointestinal function, such as loperamide. The present review explores literature on loperamide in treating TD. Adhering to manufacturer's dosage recommendations, loperamide offers a safe and effective alternative for relieving mild and moderate symptoms. Moreover, loperamide taken singly does no predispose to contracting MDR bacteria. Most importantly, we found no proof that would show antibiotics to be significantly more effective than loperamide in treating mild/moderate TD.

Place, publisher, year, edition, pages
2016. Vol. 14, no 4, 299-312 p.
Keyword [en]
Adverse drug event, Safety, Antibiotics, Antidiarrhoeals, Antibiotic resistance
National Category
Infectious Medicine
Identifiers
URN: urn:nbn:se:uu:diva-306067DOI: 10.1016/j.tmaid.2016.06.006ISI: 000382235000003PubMedID: 27363327OAI: oai:DiVA.org:uu-306067DiVA: diva2:1039677
Available from: 2016-10-25 Created: 2016-10-24 Last updated: 2016-10-25Bibliographically approved

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