Change search
ReferencesLink to record
Permanent link

Direct link
Patient-reported outcomes and visual acuity after 12 months of anti-VEGF-treatment for sight-threatening diabetic macular edema in a real world setting
Dalarna University, School of Education, Health and Social Studies, Caring Science/Nursing. Uppsala universitet.
Dalarna University, School of Education, Health and Social Studies, Caring Science/Nursing.ORCID iD: 0000-0002-5892-9897
Show others and affiliations
2016 (English)In: Diabetes Research and Clinical Practice, ISSN 0168-8227, E-ISSN 1872-8227, Vol. 121, 157-165 p.Article in journal (Refereed) Published
Abstract [en]


To examine objective visual acuity measured with ETDRS, retinal thickness (OCT), patient reported outcome and describe levels of glycated hemoglobin and its association with the effects on visual acuity in patients treated with anti-VEGF for visual impairment due to diabetic macular edema (DME) during 12 months in a real world setting.


In this cross-sectional study, 58 patients (29 females and 29 males; mean age, 68 years) with type 1 and type 2 diabetes diagnosed with DME were included. Medical data and two questionnaires were collected; an eye-specific (NEI VFQ-25) and a generic health-related quality of life questionnaire (SF-36) were used.


The total patient group had significantly improved visual acuity and reduced retinal thickness at 4 months and remains at 12 months follow up. Thirty patients had significantly improved visual acuity, and 27 patients had no improved visual acuity at 12 months. The patients with improved visual acuity had significantly improved scores for NEI VFQ-25 subscales including general health, general vision, near activities, distance activities, and composite score, but no significant changes in scores were found in the group without improvements in visual acuity.


Our study revealed that anti-VEGF treatment improved visual acuity and central retinal thickness as well as patient-reported outcome in real world 12 months after treatment start.

Place, publisher, year, edition, pages
Elsevier, 2016. Vol. 121, 157-165 p.
Keyword [en]
Patient-reported measurements; Diabetic macular edema; Anti-VEGF treatment; Visual function
National Category
Endocrinology and Diabetes
Research subject
Health and Welfare
URN: urn:nbn:se:du-23260DOI: 10.1016/j.diabres.2016.09.015PubMedID: 27718374OAI: diva2:1037379
Available from: 2016-10-14 Created: 2016-10-14 Last updated: 2016-10-25Bibliographically approved

Open Access in DiVA

fulltext(925 kB)9 downloads
File information
File name FULLTEXT01.pdfFile size 925 kBChecksum SHA-512
Type fulltextMimetype application/pdf

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Granström, ThereseForsman, HenriettaLeksell, Janeth
By organisation
Caring Science/Nursing
In the same journal
Diabetes Research and Clinical Practice
Endocrinology and Diabetes

Search outside of DiVA

GoogleGoogle Scholar
Total: 9 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 29 hits
ReferencesLink to record
Permanent link

Direct link