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Obesogenic molecules breaching Caco-2 cells: intracellular regulation of tight junctions
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Biology Education Centre.
2016 (English)Independent thesis Advanced level (professional degree), 20 credits / 30 HE creditsStudent thesis
Abstract [en]

Impaired function of the human intestinal epithelial barrier (IEB) might allow for

permeability of harmful substances, such as obesogens, which induce obesity and further

implications. Tight junction (TJ) proteins are the key component for normal functions of the

barrier. In this master thesis, the correlation between increased TJ permeability of the IEB and

absorption of obesogens was studied. The effect of obesogens on TJ expression was also

investigated. Permeability tests performed on Caco-2 cell monolayers exposed to obesogens

showed altered permeability, indicating that obesogens might have an effect on TJ protein

expression. Furthermore, impaired monolayers showed increased permeability, which implies

that impaired functions of IEB lead to increased absorption of obesogens.

Place, publisher, year, edition, pages
2016. , 42 p.
Series
UPTEC X, 16 012
Keyword [en]
Obesogens, Bisphenol A, Bisphenol AF, Imidacloprid, Tributyltin chloride, Caco-2, Tight junctions
National Category
Medical Biotechnology Engineering and Technology
Identifiers
URN: urn:nbn:se:uu:diva-305244OAI: oai:DiVA.org:uu-305244DiVA: diva2:1036460
Educational program
Molecular Biotechnology Engineering Programme
Supervisors
Examiners
Available from: 2016-10-24 Created: 2016-10-13 Last updated: 2016-10-24Bibliographically approved

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