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Investigation into Deep Brain Stimulation Lead Designs: A Patient-Specific Simulation Study
Linköping University, Department of Biomedical Engineering, Biomedical Instrumentation. Linköping University, Faculty of Science & Engineering.ORCID iD: 0000-0002-6896-1452
Linköping University, Department of Biomedical Engineering, Biomedical Instrumentation. Linköping University, Faculty of Science & Engineering.
Linköping University, Department of Biomedical Engineering. Linköping University, Faculty of Science & Engineering. Region Östergötland, Anaesthetics, Operations and Specialty Surgery Center, Department of Neurosurgery.
Region Östergötland, Anaesthetics, Operations and Specialty Surgery Center, Department of Neurosurgery. Linköping University, Department of Clinical and Experimental Medicine, Division of Neuro and Inflammation Science. Linköping University, Faculty of Medicine and Health Sciences.
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Number of Authors: 5
2016 (English)In: Brain Sciences, ISSN 2076-3425, E-ISSN 2076-3425, Vol. 6, no 3, 1-16 p.Article in journal (Refereed) Published
Abstract [en]

New deep brain stimulation (DBS) electrode designs offer operation in voltage and current mode and capability to steer the electric field (EF). The aim of the study was to compare the EF distributions of four DBS leads at equivalent amplitudes (3 V and 3.4 mA). Finite element method (FEM) simulations (n = 38) around cylindrical contacts (leads 3389, 6148) or equivalent contact configurations (leads 6180, SureStim1) were performed using homogeneous and patient-specific (heterogeneous) brain tissue models. Steering effects of 6180 and SureStim1 were compared with symmetric stimulation fields. To make relative comparisons between simulations, an EF isolevel of 0.2 V/mm was chosen based on neuron model simulations (n = 832) applied before EF visualization and comparisons. The simulations show that the EF distribution is largely influenced by the heterogeneity of the tissue, and the operating mode. Equivalent contact configurations result in similar EF distributions. In steering configurations, larger EF volumes were achieved in current mode using equivalent amplitudes. The methodology was demonstrated in a patient-specific simulation around the zona incerta and a “virtual” ventral intermediate nucleus target. In conclusion, lead design differences are enhanced when using patient-specific tissue models and current stimulation mode.

Place, publisher, year, edition, pages
MDPI , 2016. Vol. 6, no 3, 1-16 p.
Keyword [en]
deep brain stimulation (DBS), steering, patient-specific, electric field, finite element method, neuron model, brain model, zona incerta (ZI), electrode design
National Category
Medical Engineering
Identifiers
URN: urn:nbn:se:liu:diva-131863DOI: 10.3390/brainsci6030039PubMedID: 27618109OAI: oai:DiVA.org:liu-131863DiVA: diva2:1034148
Available from: 2016-10-11 Created: 2016-10-11 Last updated: 2016-11-07Bibliographically approved

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Alonso, FabiolaLatorre, MalcolmGöransson, NathanaelZsigmond, PeterWårdell, karin
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Biomedical InstrumentationFaculty of Science & EngineeringDepartment of Biomedical EngineeringDepartment of NeurosurgeryDivision of Neuro and Inflammation ScienceFaculty of Medicine and Health Sciences
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