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Roles of d-Amino Acids on the Bioactivity of Host Defense Peptides
Mahidol Univ, Fac Med Technol, Ctr Data Min & Biomed Informat, Bangkok 10700, Thailand..
Mahidol Univ, Fac Med Technol, Ctr Data Min & Biomed Informat, Bangkok 10700, Thailand..
Mahidol Univ, Fac Med Technol, Ctr Data Min & Biomed Informat, Bangkok 10700, Thailand..
Mahidol Univ, Fac Med Technol, Dept Clin Microbiol & Appl Technol, Bangkok 10700, Thailand..
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2016 (English)In: International Journal of Molecular Sciences, ISSN 1422-0067, E-ISSN 1422-0067, Vol. 17, no 7, 1023Article, review/survey (Refereed) Published
Abstract [en]

Host defense peptides (HDPs) are positively-charged and amphipathic components of the innate immune system that have demonstrated great potential to become the next generation of broad spectrum therapeutic agents effective against a vast array of pathogens and tumor. As such, many approaches have been taken to improve the therapeutic efficacy of HDPs. Amongst these methods, the incorporation of d-amino acids (d-AA) is an approach that has demonstrated consistent success in improving HDPs. Although, virtually all HDP review articles briefly mentioned about the role of d-AA, however it is rather surprising that no systematic review specifically dedicated to this topic exists. Given the impact that d-AA incorporation has on HDPs, this review aims to fill that void with a systematic discussion of the impact of d-AA on HDPs.

Place, publisher, year, edition, pages
2016. Vol. 17, no 7, 1023
Keyword [en]
d-amino acid, host defense peptide, antimicrobial peptide, anticancer peptide, diastereomer, HDP, AMP, bioactivity
National Category
Medical Biotechnology (with a focus on Cell Biology (including Stem Cell Biology), Molecular Biology, Microbiology, Biochemistry or Biopharmacy)
Identifiers
URN: urn:nbn:se:uu:diva-304683DOI: 10.3390/ijms17071023ISI: 000381500900038OAI: oai:DiVA.org:uu-304683DiVA: diva2:1033502
Funder
Swedish Research Council, C0610701
Available from: 2016-10-07 Created: 2016-10-07 Last updated: 2017-11-30Bibliographically approved

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Wikberg, Jarl E. S.
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