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Preliminary investigations into the behavior of urea: succinic acid co-crystals on scale-up by batch crystallizations
2008 (English)Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
Abstract [en]

Crystallization is an important method used for purification and in production of solid form of pharmaceutical products. Screening of urea and succinic acid in different organic solvents was conducted to identify the most suitable solvent for crystallization process. The screening process produced isopropanol as the most suitable solvent. Cooling crystallization was carried out using Julabo Easy Temp software for temperature control with 100Pt IKA temperature sensor inserted in the crystallizer for temperature monitoring. Solubility studies of urea- succinic acid co-crystals were conducted, using an HPLC method, to find a cooling profile so as to determine the effects of process parameters on the quality of products obtained. The solubility of urea-succinate co- crystals was found to be temperature dependent because at a fixed stirring rate, solubility decreases with decrease in temperature . DSC, PXRD, and Raman data confirmed the formation and stability of urea-succinate co- crystals on scale-up. The process parameters of stirring rate, cooling rate and temperature had no significant influence on urea-succinic acid co- crystals on scale-up.

Place, publisher, year, edition, pages
Keyword [en]
Physics Chemistry Maths, solubility, urea, succinic acid, co-crystals, synthon
Keyword [sv]
Fysik, Kemi, Matematik
URN: urn:nbn:se:ltu:diva-55715ISRN: LTU-PB-EX--08/067--SELocal ID: c8b3885e-563d-455c-8ca3-cc1e8e060de4OAI: diva2:1029099
Subject / course
Student thesis, at least 30 credits
Educational program
Chemical Engineering, master's level
Validerat; 20101217 (root)Available from: 2016-10-04 Created: 2016-10-04Bibliographically approved

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