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Formulation and evaluation of zolmitriptan fast disintegrated tablets prepared by direct compression
2009 (English)Independent thesis Basic level (professional degree), 10 credits / 15 HE creditsStudent thesis
Abstract [en]

The aim of this study was to study the effect of disintegrate type on the characteristics of fast disintegrating sublingual tablets. It was also to study the effect of applied pressure on disintegration time. Two tablet formulations, A and B contain polyplasdone and sodium starch glycolate respectively were prepared. Also, tablets from formulation B were prepared at different pressure. Tablets were evaluated for weight variation, content uniformity, thickness, diameter, friability and disintegration time. All tablets were within the European Pharmacopoeia (EP) limits for weight variation and content uniformity. The disintegration time fulfill the EP requirements. The disintegration time of formulation A was faster than formulation B. The applied pressure has a significant effect on tablet disintegration. Polyplasdone is more efficient to promote fast disintegration than starch. The pressure used for tablet preparation should be optimized to meet the required disintegration time for tablet.

Place, publisher, year, edition, pages
2009.
Keyword [en]
Medicine, Disintegration, Tablet, Zolmitriptan, Direct Compression
Keyword [sv]
Medicin
Identifiers
URN: urn:nbn:se:ltu:diva-53119ISRN: LTU-HV-EX--09/11--SELocal ID: a2fbd715-da58-42f7-99f0-3708539cb8bbOAI: oai:DiVA.org:ltu-53119DiVA: diva2:1026493
Subject / course
Student thesis, at least 15 credits
Educational program
Prescriptionist, bachelor's level
Examiners
Note
Validerat; 20101217 (root)Available from: 2016-10-04 Created: 2016-10-04Bibliographically approved

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CiteExportLink to record
Permanent link

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Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf