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Effects of interactive patient smartphone support app on drug adherence and lifestyle changes in myocardial infarction patients: A randomized study
Uppsala University, Sweden; Uppsala University, Sweden.
AstraZeneca Nordic Balt, Sweden.
AstraZeneca Nordic Balt, Sweden.
AstraZeneca Nordic Balt, Sweden.
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2016 (English)In: American Heart Journal, ISSN 0002-8703, E-ISSN 1097-6744, Vol. 178, 85-94 p.Article in journal (Refereed) Published
Abstract [en]

Background Patients with myocardial infarction (MI) seldom reach recommended targets for secondary prevention. This study evaluated a smartphone application ("app") aimed at improving treatment adherence and cardiovascular lifestyle in MI patients. Design Multicenter, randomized trial. Methods A total of 174 ticagrelor-treated MI patients were randomized to either an interactive patient support tool (active group) or a simplified tool (control group) in addition to usual post-MI care. Primary end point was a composite nonadherence score measuring patient-registered ticagrelor adherence, defined as a combination of adherence failure events (2 missed doses registered in 7-day cycles) and treatment gaps (4 consecutive missed doses). Secondary end points included change in cardiovascular risk factors, quality of life (European Quality of Life-5 Dimensions), and patient device satisfaction (System Usability Scale). Results Patient mean age was 58 years, 81% were men, and 21% were current smokers. At 6 months, greater patient registered drug adherence was achieved in the active vs the control group (nonadherence score: 16.6 vs 22.8 [P = .025]). Numerically, the active group was associated with higher degree of smoking cessation, increased physical activity, and change in quality of life; however, this did not reach statistical significance. Patient satisfaction was significantly higher in the active vs the control group (system usability score: 87.3 vs 78.1 [P = .001]). Conclusions In MI patients, use of an interactive patient support tool improved patient self-reported drug adherence and may be associated with a trend toward improved cardiovascular lifestyle changes and quality of life. Use of a disease-specific interactive patient support tool may be an appreciated, simple, and promising complement to standard secondary prevention.

Place, publisher, year, edition, pages
MOSBY-ELSEVIER , 2016. Vol. 178, 85-94 p.
National Category
Cardiac and Cardiovascular Systems
URN: urn:nbn:se:liu:diva-131690DOI: 10.1016/j.ahj.2016.05.005ISI: 000381590300010PubMedID: 27502855OAI: diva2:1013456

Funding Agencies|AstraZeneca; Amgen; Sanofi-Aventis; Novartis; Merck Sharp Dome; Bristol-Meyers Squibb; Eli-Lilly; Medicines Company; Bristol Myers Squibb; Pfizer; CSL Behring; Bristol Myers

Available from: 2016-10-03 Created: 2016-09-30 Last updated: 2016-11-02

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Alfredsson, JoakimKarlsson, Jan-Erik
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Division of Cardiovascular MedicineFaculty of Medicine and Health SciencesDepartment of Cardiology in Linköping
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