Change search
ReferencesLink to record
Permanent link

Direct link
Levodopa-carbidopa intestinal gel (LCIG) treatment in routine care of patients with advanced Parkinsons disease: An open-label prospective observational study of effectiveness, tolerability and healthcare costs
Karolinska University Hospital, Sweden.
Karolinska University Hospital, Sweden.
Uppsala University, Sweden.
Uppsala University, Sweden.
Show others and affiliations
2016 (English)In: Parkinsonism & Related Disorders, ISSN 1353-8020, E-ISSN 1873-5126, Vol. 29, 17-23 p.Article in journal (Refereed) Published
Abstract [en]

Background: Continuous infusion of levodopa-carbidopa intestinal gel (LCIG) can effectively manage motor and non-motor complications in advanced Parkinsons disease (PD). Healthcare costs, quality of life (QoL), effectiveness, and tolerability were assessed in routine care treatment with LCIG. Methods: The seventy-seven patients enrolled in this prospective, open-label, 3-year study in routine medical care were LCIG-naive (N = 37), or had previous LCIG treatment for amp;lt;2 (N = 22), or amp;gt;= 2 (N = 18) years. Healthcare costs were collected monthly. PD symptoms and QoL were assessed with the Unified Parkinsons Disease Rating Scale (UPDRS), 39-item Parkinsons Disease Questionnaire (PDQ-39), and EuroQoL 5-Dimension Visual Analog Scale (EQ-5D VAS); LCIG dose, safety, and tolerability were monitored. Results: Mean monthly costs per patient ( 8226 5952) were similar across cohorts, remained steady during 3-year follow-up, and increased with PD severity and QoL impairment. In LCIG-naive patients, significant improvements compared to baseline were observed on the UPDRS total score and PDQ-39 summary index score through 18 months (n = 24; UPDRS, p = 0.033; PDQ-39, p = 0.049). Symptom control was maintained during 3-year follow-up in LCIG-experienced cohorts. Small changes in mean daily LCIG dose were observed. Adverse events were common and generally related to the device, procedure, levodopa, or laboratory evaluations. Conclusions: Costs in LCIG-treated patients were stable over 3 years. LCIG treatment led to significant improvements in motor function and QoL over 18 months in LCIG-naive patients and no worsening was observed in LCIG-experienced patients over 3 years despite natural PD progression over time. The longterm safety was consistent with the established LCIG profile. (C) 2016 AbbVie Inc. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

Place, publisher, year, edition, pages
ELSEVIER SCI LTD , 2016. Vol. 29, 17-23 p.
Keyword [en]
Parkinsons disease; Levodopa; Infusion; LCIG; Cost
National Category
Neurology
Identifiers
URN: urn:nbn:se:liu:diva-131707DOI: 10.1016/j.parkreldis.2016.06.002ISI: 000381955700004PubMedID: 27318707OAI: oai:DiVA.org:liu-131707DiVA: diva2:1010256
Note

Funding Agencies|AbbVie Inc.

Available from: 2016-10-03 Created: 2016-09-30 Last updated: 2016-11-02

Open Access in DiVA

fulltext(768 kB)8 downloads
File information
File name FULLTEXT01.pdfFile size 768 kBChecksum SHA-512
068908e8e2e570f1ac9a14c59ae689209f4c775820a59e7346a142d5e7c2cae73a556782cd17f406b8e82d8e3eb7b672fc2ff6d07d67e29b28edb704bad1a2ab
Type fulltextMimetype application/pdf

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Dizdar-Segrell, Nil
By organisation
Division of Neuro and Inflammation ScienceFaculty of Medicine and Health SciencesDepartment of Neurology
In the same journal
Parkinsonism & Related Disorders
Neurology

Search outside of DiVA

GoogleGoogle Scholar
Total: 8 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 9 hits
ReferencesLink to record
Permanent link

Direct link