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A fully integrated microfluidic device for point of care monitoring of antithrombotics
Dublin Institute Technology, Ireland.
Queens University of Belfast, North Ireland.
Linköping University, Department of Clinical and Experimental Medicine, Division of Microbiology and Molecular Medicine. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Center for Diagnostics, Department of Clinical Chemistry.
University of West England, England.
2016 (English)In: Analytical Methods, ISSN 1759-9660, E-ISSN 1759-9679, Vol. 8, no 35, 6500-6505 p.Article in journal (Refereed) Published
Abstract [en]

The simplicity and efficiency of point of care diagnostics have revolutionised patient care. Current methods for measuring hypercoagulability often require trained technicians, large blood volumes, and result in long turnaround times. Standard testing for hypercoagulable disorders is performed in the central laboratory using automated coagulation analysers. However the trend is moving towards the development and implementation of point of care testing, as a result of the ever increasing number of patients on antithrombotic therapy. We present a novel microfluidic device and assay for monitoring the effect of two anticoagulants, unfractionated heparin (UFH) and low molecular weight heparin (LMWH). The assay is based on the anti-Xa assay principle but uses fluorescence detection. Our device is a disposable laminate microfluidic strip, fabricated from the cyclic polyolefin (COP), Zeonor (R), which is extremely suitable for application to fluorescent device platforms. We present data on the execution of the anti-Xa assay in this microfluidic format, demonstrating that the assay can be used to measure both UFH and LMWH in human plasma samples from 0 to 1 U mL(-1), with a rapid result obtained within 30-60 seconds.

Place, publisher, year, edition, pages
ROYAL SOC CHEMISTRY , 2016. Vol. 8, no 35, 6500-6505 p.
National Category
Analytical Chemistry
Identifiers
URN: urn:nbn:se:liu:diva-131721DOI: 10.1039/c6ay01566bISI: 000382673400004OAI: oai:DiVA.org:liu-131721DiVA: diva2:1010222
Note

Funding Agencies|Enterprise Ireland [TD/2009/0124]

Available from: 2016-10-03 Created: 2016-09-30 Last updated: 2017-08-29

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