Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
In situ scanning probe microscopy studies of morphology and growth kinetics in amyloid-peptide fibrillogenesis with custom designed tapping mode and pulsed force mode systems
Luleå University of Technology, Department of Engineering Sciences and Mathematics, Material Science.
Show others and affiliations
2004 (English)In: Proceedings of 5th Nordic-Baltic Scanning Probe Microscopy Workshop, 2004, 93-95 p.Conference paper, Meeting abstract (Refereed)
Abstract [en]

We have used a commercial Nanoscope II atomic force microscope (AFM) with a custom designedtapping mode (TM) system to in situ monitor amyloid β-peptide aggregation related to Alzheimer’sdisease (AD). The custom tapping mode setup was successfully used to image the real timeaggregation behaviour of the arctic mutation amyloid β-peptide, Aβ(1-40), in vitro in aphysiologically relevant buffer and compare with the behaviour of the normal wild type of theAlzheimer’s amyloid peptide Aβ(1-40) at the same conditions. The investigation revealed distinctdifferences in fibrillogenesis behaviour for the two peptides. Our results demonstrate a previouslysuggested alternative fibrillogenesis pathway, of highly distinct aggregates with orderedmorphology as on-pathway. Moreover, additional investigations using a pulsed force mode (PFM)are under way.

Place, publisher, year, edition, pages
2004. 93-95 p.
National Category
Physical Chemistry Other Physics Topics Other Physics Topics
Research subject
Chemistry of Interfaces; Fysik; Experimental physics
Identifiers
URN: urn:nbn:se:ltu:diva-35310Local ID: 9cb9e1b4-8f99-450e-ae7c-81bc5342e8bfOAI: oai:DiVA.org:ltu-35310DiVA: diva2:1008563
Conference
Nordic-Baltic Scanning Probe Microscopy Workshop : 16/06/2004 - 19/06/2004
Note
Godkänd; 2004; 20120626 (nils)Available from: 2016-09-30 Created: 2016-09-30 Last updated: 2017-11-25Bibliographically approved

Open Access in DiVA

fulltext(164 kB)14 downloads
File information
File name FULLTEXT01.pdfFile size 164 kBChecksum SHA-512
00ffd510069ce63a1eb6464cbd011def2befeffbb570e1ba5497da5e91357ee0e3903a91d7d3829c8f4c2241bc31c24060628793ec65c72b9988994c5006a615
Type fulltextMimetype application/pdf

Search in DiVA

By author/editor
Olevik, DavidAlmqvist, NilsAntzutkin, Oleg
By organisation
Material ScienceSustainable Process Engineering
Physical ChemistryOther Physics TopicsOther Physics Topics

Search outside of DiVA

GoogleGoogle Scholar
Total: 14 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

urn-nbn

Altmetric score

urn-nbn
Total: 28 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf