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Home- or Institutional Hemodialysis? - a Matched Pair-Cohort Study Comparing Survival and Some Modifiable Factors Related to Survival
Lund University, Sweden.
Lund University, Sweden.
Linköping University, Department of Medical and Health Sciences, Division of Drug Research. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Heart and Medicine Center, Department of Nephrology.
2016 (English)In: Kidney and Blood Pressure Research, ISSN 1420-4096, E-ISSN 1423-0143, Vol. 41, no 4, 392-401 p.Article in journal (Refereed) Published
Abstract [en]

Background/Aims: Survival for dialysis patients is poor. Earlier studies have shown better survival in home-hemodialysis (HHD). The aims of this study are to compare survival for matched patients with HHD and institutional hemodialysis (IHD) and to elucidate the effect on factors related to survival such as hyperphosphatemia, fluid overload and anemia. Methods: In this retrospective, observational study, incident patients starting HHD and IHD were matched according to sex, age, comorbidity and date of start. Survival analysis was performed both as "intention to treat" including renal transplantation and "on treatment" with censoring at the date of transplantation. Dialysis doses, laboratory parameters and prescriptions of medications were compared. Results: After matching, 41 pairs of patients, with HHD and IHD, were included. Survival among HHD patients was longer compared with IHD, median survival being 17.3 and 13.0 years (p=0.016), respectively. The "on treatment" analysis, also favoured HHD (p=0.015). HHD patients had lower phosphate, 1.5 mmol/L compared with 2.1 mmol/L (pamp;lt;0.001) and no antihypertensives and diuretics compared with 2 for IHD patients at 6 (p=0.001) and 18 months (p=0.014). There were no differences in hemoglobin or albumin. Conclusion: HHD shows better survival compared with IHD, also after controlling for patient selection. This could be caused by better phosphate and/or fluid balance associated with higher dialysis doses. (C) 2016 The Author(s) Published by S. Karger AG, Basel

Place, publisher, year, edition, pages
KARGER , 2016. Vol. 41, no 4, 392-401 p.
Keyword [en]
Survival; Home hemodialysis; Hypertension; Volume control; Calcium and phosphate metabolism
National Category
Cardiac and Cardiovascular Systems
Identifiers
URN: urn:nbn:se:liu:diva-131730DOI: 10.1159/000443441ISI: 000382740300005PubMedID: 27344461OAI: oai:DiVA.org:liu-131730DiVA: diva2:1006905
Note

Funding Agencies|Skane Regional Council; Southern Health Care Region in Sweden; Paul Frankenius Foundation; Swedish Society of Nephrology

Available from: 2016-09-30 Created: 2016-09-30 Last updated: 2016-10-19

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Segelmark, Mårten
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