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Maintaining high anaerobic succinic acid productivity by product removal
Luleå tekniska universitet.
Luleå tekniska universitet, Institutionen för samhällsbyggnad och naturresurser, Industriell miljö- och processteknik.ORCID-id: 0000-0001-7500-2367
2010 (engelsk)Inngår i: Bioprocess and biosystems engineering (Print), ISSN 1615-7591, E-ISSN 1615-7605, Vol. 33, nr 6, s. 711-718Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

During dual-phase fermentations using Escherichia coli engineered for succinic acid production, the productivity and viable cell concentration decrease as the concentration of succinic acid increases. The effects of succinic acid on the fermentation kinetics, yield, and cell viability were investigated by resuspending cells in fresh media after selected fermentation times. The cellular succinic acid productivity could be restored, but cell viability continuously decreased throughout the fermentations by up to 80% and subsequently the volumetric productivity was reduced. Omitting complex nutrients in the resuspension media had no significant effect on cellular succinate productivity and yield, although the viable cell concentration and thus the volumetric productivity was reduced by approximately 20%. By resuspending the cells, the amount of succinate produced during a 100-h fermentation was increased by more than 60%. The results demonstrate that by product removal succinic acid productivity can be maintained at high levels for extended periods of time.

sted, utgiver, år, opplag, sider
2010. Vol. 33, nr 6, s. 711-718
HSV kategori
Forskningsprogram
Biokemisk processteknik
Identifikatorer
URN: urn:nbn:se:ltu:diva-13845DOI: 10.1007/s00449-009-0393-yISI: 000279830800007PubMedID: 19921276Scopus ID: 2-s2.0-77956061846Lokal ID: d227e870-e316-11de-bae5-000ea68e967bOAI: oai:DiVA.org:ltu-13845DiVA, id: diva2:986798
Merknad
Validerad; 2010; 20091207 (ysko)Tilgjengelig fra: 2016-09-29 Laget: 2016-09-29 Sist oppdatert: 2018-07-10bibliografisk kontrollert

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