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Changes in IgE sensitization and total IgE levels over 20 years of follow-up
Univ London Imperial Coll Sci Technol & Med, Resp Epidemiol Occupat Med & Publ Hlth, Natl Heart & Lung Inst, Emmanuel Kaye Bldg,1B Manresa Rd, London SW3 6LR, England..
Univ London Imperial Coll Sci Technol & Med, Resp Epidemiol Occupat Med & Publ Hlth, Natl Heart & Lung Inst, Emmanuel Kaye Bldg,1B Manresa Rd, London SW3 6LR, England.;Univ London Imperial Coll Sci Technol & Med, Dept Primary Care & Publ Hlth, Sch Publ Hlth, London, England..
Monash Univ, Sch Publ Hlth & Prevent Med, Melbourne, Vic 3004, Australia..
Ctr Res Environm Epidemiol CREAL, Barcelona, Spain.;IMIM Hosp del Mar, Med Res Inst, Barcelona, Spain.;UPF, Barcelona, Spain.;CIBERESP, Madrid, Spain..
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2016 (Engelska)Ingår i: Journal of Allergy and Clinical Immunology, ISSN 0091-6749, E-ISSN 1097-6825, Vol. 137, nr 6, s. 1788-1795Artikel i tidskrift (Refereegranskat) Published
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Abstract [en]

Background: Cross-sectional studies have reported a lower prevalence of sensitization in older adults, but few longitudinal studies have examined whether this is an aging or a year-of-birth cohort effect. Objective: We sought to assess changes in sensitization and total IgE levels in a cohort of European adults as they aged over a 20-year period. Methods: Levels of serum specific IgE to common aeroallergens (house dust mite, cat, and grass) and total IgE levels were measured in 3206 adults from 25 centers in the European Community Respiratory Health Survey on 3 occasions over 20 years. Changes in sensitization and total IgE levels were analyzed by using regression analysis corrected for potential differences in laboratory equipment and by using inverse sampling probability weights to account for nonresponse. Results: Over the 20-year follow-up, the prevalence of sensitization to at least 1 of the 3 allergens decreased from 29.4% to 24.8% (-4.6%; 95% CI, -7.0% to -2.1%). The prevalence of sensitization to house dust mite (-4.3%; 95% CI, -6.0% to -2.6%) and cat (-2.1%; 95% CI, -3.6% to -0.7%) decreased more than sensitization to grass (-0.6%; 95% CI, -2.5% to 1.3%). Age-specific prevalence of sensitization to house dust mite and cat did not differ between year-of-birth cohorts, but sensitization to grass was most prevalent in the most recent ones. Overall, total IgE levels decreased significantly (geometric mean ratio, 0.63; 95% CI, 0.58-0.68) at all ages in all year-of-birth cohorts. Conclusion: Aging was associated with lower levels of sensitization, especially to house dust mite and cat, after the age of 20 years.

Ort, förlag, år, upplaga, sidor
2016. Vol. 137, nr 6, s. 1788-1795
Nyckelord [en]
Allergens, sensitization, cohort study, epidemiology, IgE, longitudinal analysis, aging, immunosenescence
Nationell ämneskategori
Lungmedicin och allergi Immunologi inom det medicinska området
Identifikatorer
URN: urn:nbn:se:uu:diva-299060DOI: 10.1016/j.jaci.2015.09.037ISI: 000377527200020PubMedID: 26586040OAI: oai:DiVA.org:uu-299060DiVA, id: diva2:948775
Forskningsfinansiär
Deutsche Forschungsgemeinschaft (DFG), FR1526/1-1; HE 3294/10-1;MA 711/4-1; NO 262/7-1Hjärt-LungfondenAstma- och AllergiförbundetCancer- och AllergifondenForte, Forskningsrådet för hälsa, arbetsliv och välfärdEU, Europeiska forskningsrådet, 018996-GABRIELWellcome trustTillgänglig från: 2016-07-13 Skapad: 2016-07-13 Senast uppdaterad: 2018-02-19Bibliografiskt granskad

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Janson, Christer
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Lungmedicin och allergologiLung- allergi- och sömnforskning
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Journal of Allergy and Clinical Immunology
Lungmedicin och allergiImmunologi inom det medicinska området

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