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CD161(int)CD8+T cells: a novel population of highly functional, memory CD8+T cells enriched within the gut
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Antal upphovsmän: 182016 (Engelska)Ingår i: Mucosal Immunology, ISSN 1933-0219, E-ISSN 1935-3456, Vol. 9, nr 2, s. 401-413Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

The C-type lectin-like receptor CD161 is expressed by lymphocytes found in human gut and liver, as well as blood, especially natural killer (NK) cells, T helper 17 (Th17) cells, and a population of unconventional Tcells known as mucosalassociated invariant T (MAIT) cells. The association of high CD161 expression with innate T-cell populations including MAITcells is established. Here we show that CD161 is also expressed, at intermediate levels, on a prominent subset of polyclonal CD8+ T cells, including antiviral populations that display a memory phenotype. These memory CD161(int)CD8+ Tcells are enriched within the colon and express both CD103 and CD69, markers associated with tissue residence. Furthermore, this population was characterized by enhanced polyfunctionality, increased levels of cytotoxic mediators, and high expression of the transcription factors T-bet and eomesodermin (EOMES). Such populations were induced by novel vaccine strategies based on adenoviral vectors, currently in trial against hepatitis C virus. Thus, intermediate CD161 expression marks potent polyclonal, polyfunctional tissue-homing CD8+ T-cell populations in humans. As induction of such responses represents a major aim of T-cell prophylactic and therapeutic vaccines in viral disease and cancer, analysis of these populations could be of value in the future.

Ort, förlag, år, upplaga, sidor
2016. Vol. 9, nr 2, s. 401-413
Nationell ämneskategori
Biologiska vetenskaper Immunologi inom det medicinska området
Identifikatorer
URN: urn:nbn:se:su:diva-129634DOI: 10.1038/mi.2015.69ISI: 000372425800010PubMedID: 26220166OAI: oai:DiVA.org:su-129634DiVA, id: diva2:925014
Tillgänglig från: 2016-04-29 Skapad: 2016-04-26 Senast uppdaterad: 2018-01-10Bibliografiskt granskad

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Sverremark-Ekström, Eva
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Institutionen för molekylär biovetenskap, Wenner-Grens institut
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Mucosal Immunology
Biologiska vetenskaperImmunologi inom det medicinska området

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