Ändra sökning
RefereraExporteraLänk till posten
Permanent länk

Direktlänk
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
Complement receptor 2 is increased in cerebrospinal fluid of multiple sclerosis patients and regulates C3 function
Karolinska Institutet;Uppsala University.
Karolinska Institutet.
Karolinska Institutet.
Karolinska Institutet.
Visa övriga samt affilieringar
2016 (Engelska)Ingår i: Clinical Immunology, ISSN 1521-6616, E-ISSN 1521-7035, Vol. 166, s. 89-95Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Besides its vital role in immunity, the complement system also contributes to the shaping of the synaptic circuitry of the brain. We recently described that soluble Complement Receptor 2 (sCR2) is part of the nerve injury response in rodents. We here study CR2 in context of multiple sclerosis (MS) and explore the molecular effects of CR2 on C3 activation.

Significant increases in sCR2 levels were evident in cerebrospinal fluid (CSF) from both patients with relapsing-remitting MS (n = 33; 6.2 ng/mL) and secondary-progressive MS (n = 9; 7.0 ng/mL) as compared to controls (n = 18; 4.1 ng/mL). Furthermore, CSF sCR2 levels correlated significantly both with CSF C3 and C1q as well as to a disease severity measure. In vitro, sCR2 inhibited the cleavage and down regulation of C3b to iC3b, suggesting that it exerts a modulatory role in complement activation downstream of C3.

These results propose a novel function for CR2/sCR2 in human neuroinflammatory conditions.

Ort, förlag, år, upplaga, sidor
2016. Vol. 166, s. 89-95
Nationell ämneskategori
Immunologi inom det medicinska området
Forskningsämne
Biomedicinsk vetenskap, Immunologi
Identifikatorer
URN: urn:nbn:se:lnu:diva-52309DOI: 10.1016/j.clim.2016.04.003ISI: 000378011500010PubMedID: 27085202Scopus ID: 2-s2.0-84963963835OAI: oai:DiVA.org:lnu-52309DiVA, id: diva2:924696
Tillgänglig från: 2016-04-28 Skapad: 2016-04-28 Senast uppdaterad: 2018-11-16Bibliografiskt granskad

Open Access i DiVA

Fulltext saknas i DiVA

Övriga länkar

Förlagets fulltextPubMedScopus

Sök vidare i DiVA

Av författaren/redaktören
Sandholm, KerstinNilsson Ekdahl, Kristina
Av organisationen
Institutionen för kemi och biomedicin (KOB)
I samma tidskrift
Clinical Immunology
Immunologi inom det medicinska området

Sök vidare utanför DiVA

GoogleGoogle Scholar

doi
pubmed
urn-nbn

Altmetricpoäng

doi
pubmed
urn-nbn
Totalt: 344 träffar
RefereraExporteraLänk till posten
Permanent länk

Direktlänk
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf