Endre søk
RefereraExporteraLink to record
Permanent link

Direct link
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
Case definitions in Swedish register data to identify systemic lupus erythematosus
Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Reumatologi.
Vise andre og tillknytning
2016 (engelsk)Inngår i: BMJ Open, ISSN 2044-6055, E-ISSN 2044-6055, Vol. 6, nr 1, artikkel-id e007769Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

OBJECTIVE: To develop and investigate the utility of several different case definitions for systemic lupus erythematosus (SLE) using national register data in Sweden.

METHODS: The reference standard consisted of clinically confirmed SLE cases pooled from four major clinical centres in Sweden (n=929), and a sample of non-SLE comparators randomly selected from the National Population Register (n=24 267). Demographics, comorbidities, prescriptions and autoimmune disease family history were obtained from multiple registers and linked to the reference standard. We first used previously published SLE definitions to create algorithms for SLE. We also used modern data mining techniques (penalised least absolute shrinkage and selection operator logistic regression, elastic net regression and classification trees) to objectively create data-driven case definitions. Sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) were calculated for the case definitions identified.

RESULTS: Defining SLE by using only hospitalisation data resulted in the lowest sensitivity (0.79). When SLE codes from the outpatient register were included, sensitivity and PPV increased (PPV between 0.97 and 0.98, sensitivity between 0.97 and 0.99). Addition of medication information did not greatly improve the algorithm's performance. The application of data mining methods did not yield different case definitions.

CONCLUSIONS: The use of SLE International Classification of Diseases (ICD) codes in outpatient clinics increased the accuracy for identifying individuals with SLE using Swedish registry data. This study implies that it is possible to use ICD codes from national registers to create a cohort of individuals with SLE.

sted, utgiver, år, opplag, sider
2016. Vol. 6, nr 1, artikkel-id e007769
HSV kategori
Identifikatorer
URN: urn:nbn:se:uu:diva-278034DOI: 10.1136/bmjopen-2015-007769ISI: 000369993900007PubMedID: 26729375OAI: oai:DiVA.org:uu-278034DiVA, id: diva2:906058
Forskningsfinansiär
Stockholm County CouncilSwedish Research CouncilSwedish Heart Lung FoundationSwedish Rheumatism AssociationTilgjengelig fra: 2016-02-23 Laget: 2016-02-23 Sist oppdatert: 2017-11-30bibliografisk kontrollert

Open Access i DiVA

fulltext(762 kB)214 nedlastinger
Filinformasjon
Fil FULLTEXT01.pdfFilstørrelse 762 kBChecksum SHA-512
503c7bac7f7c1894d45ecbb2c79fe7c68b4610ea80213ea6cb2ae072577e326916faef373b7fa85b29bc2bd534072a53e35e440e2f51951ec65db6a620b88aa2
Type fulltextMimetype application/pdf

Andre lenker

Forlagets fulltekstPubMed

Søk i DiVA

Av forfatter/redaktør
Rönnblom, Lars
Av organisasjonen
I samme tidsskrift
BMJ Open

Søk utenfor DiVA

GoogleGoogle Scholar
Totalt: 214 nedlastinger
Antall nedlastinger er summen av alle nedlastinger av alle fulltekster. Det kan for eksempel være tidligere versjoner som er ikke lenger tilgjengelige

doi
pubmed
urn-nbn

Altmetric

doi
pubmed
urn-nbn
Totalt: 639 treff
RefereraExporteraLink to record
Permanent link

Direct link
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf