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Susceptibility to infections, without concomitant hyper-IgE, reported in 1976, is caused by hypomorphic mutation in the phosphoglucomutase 3 (PGM3) gene
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2015 (Engelska)Ingår i: Clinical Immunology, ISSN 1521-6616, E-ISSN 1521-7035, Vol. 161, nr 2, s. 366-372Artikel i tidskrift (Refereegranskat) Published
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Abstract [en]

Phosphoglucomutase 3 (PGM3) is an enzyme converting N-acetyl-glucosamine-6-phosphate to N-acetylglucosamine-l-phosphate, a precursor important for glycosylation. Mutations in the PGM3 gene have recently been identified as the cause of novel primary immunodeficiency with a hyper-IgE like syndrome. Here we report the occurrence of a homozygous mutation in the PGM3 gene in a family with immunodeficient children, described already in 1976. DNA from two of the immunodeficient siblings was sequenced and shown to encode the same homozygous missense mutation, causing a destabilized protein with reduced enzymatic capacity. Affected individuals were highly prone to infections, but lack the developmental defects in the nervous and skeletal systems, reported in other families. Moreover, normal IgE levels were found. Thus, belonging to the expanding group of congenital glycosylation defects, PGM3 deficiency is characterized by immunodeficiency, with or without increased IgE levels, and with variable forms of developmental defects affecting other organ systems.

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Elsevier, 2015. Vol. 161, nr 2, s. 366-372
Nyckelord [en]
Primary immunodeficiency, N-acetylglucosamine-phosphate mutase hyper-IgE syndrome, Congenital fects of glycosylation, CDG
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Immunologi inom det medicinska området
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URN: urn:nbn:se:umu:diva-113722DOI: 10.1016/j.clim.2015.10.002ISI: 000365831600042PubMedID: 26482871OAI: oai:DiVA.org:umu-113722DiVA, id: diva2:890056
Tillgänglig från: 2015-12-30 Skapad: 2015-12-28 Senast uppdaterad: 2018-06-07Bibliografiskt granskad

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