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Outcome of microdialysis sampling on liver surface and parenchyma
Umeå universitet, Medicinska fakulteten, Institutionen för kirurgisk och perioperativ vetenskap, Anestesiologi och intensivvård.
Umeå universitet, Medicinska fakulteten, Institutionen för kirurgisk och perioperativ vetenskap, Anestesiologi och intensivvård.ORCID-id: 0000-0002-5325-2688
Umeå universitet, Medicinska fakulteten, Institutionen för kirurgisk och perioperativ vetenskap, Anestesiologi och intensivvård.
Umeå universitet, Medicinska fakulteten, Institutionen för kirurgisk och perioperativ vetenskap, Anestesiologi och intensivvård.
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2016 (Engelska)Ingår i: Journal of Surgical Research, ISSN 0022-4804, E-ISSN 1095-8673, Vol. 200, nr 2, s. 480-487Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Background: To investigate whether surface microdialysis (μD) sampling in probes covered by a plastic film, as compared to noncovered and to intraparenchymatous probes, would increase the technique's sensitivity for pathophysiologic events occurring in a liver ischemia-reperfusion model. Placement of μD probes in the parenchyma of an organ, as is conventionally done, may cause adverse effects, e.g., bleeding, possibly influencing outcome.

Methods: A transient ischemia-reperfusion model of the liver was used in six anesthetized normoventilated pigs. μD probes were placed in the parenchyma and on the liver surface. Surface probes were either left uncovered or were covered by plastic film.

Results: Lactate and glucose levels were significantly higher in plastic film covered probes than in uncovered surface probes throughout the ischemic period. Glycerol levels were significantly higher in plastic film covered probes than in uncovered surface probes at 30 and 45 min into ischemia.

Conclusions: Covering the μD probe increases the sensibility of the μD–technique in monitoring an ischemic insult and reperfusion in the liver. These findings confirm that the principle of surface μD works, possibly replacing need of intraparenchymatous placement of μD probes. Surface μD seemingly allows, noninvasively from an organ's surface, via the extracellular compartment, assessment of intracellular metabolic events. The finding that covered surface μD probes allows detection of local metabolic changes earlier than do intraparenchymatous probes, merit further investigation focusing on μD probe design.

Ort, förlag, år, upplaga, sidor
2016. Vol. 200, nr 2, s. 480-487
Nyckelord [en]
Microdialysis, Liver, Ischemia, Reperfusion, Surface probe, Metabolism
Nationell ämneskategori
Fysiologi Biomedicinsk laboratorievetenskap/teknologi Kirurgi
Identifikatorer
URN: urn:nbn:se:umu:diva-112153DOI: 10.1016/j.jss.2015.09.009ISI: 000366841500010PubMedID: 26505659OAI: oai:DiVA.org:umu-112153DiVA, id: diva2:876273
Tillgänglig från: 2015-12-03 Skapad: 2015-12-03 Senast uppdaterad: 2018-06-07Bibliografiskt granskad

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Abrahamsson, PernillaJohansson, GöranÅberg, Anna-MajaWinsö, OlaBlind, Per Jonas
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Anestesiologi och intensivvårdKirurgi
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Journal of Surgical Research
FysiologiBiomedicinsk laboratorievetenskap/teknologiKirurgi

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