Endre søk
RefereraExporteraLink to record
Permanent link

Direct link
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
The lateral reticular nucleus: integration of descending and ascending systems regulating voluntary forelimb movements
Umeå universitet, Medicinska fakulteten, Institutionen för integrativ medicinsk biologi (IMB), Fysiologi.
2015 (engelsk)Inngår i: Frontiers in Computational Neuroscience, ISSN 1662-5188, E-ISSN 1662-5188, Vol. 9, artikkel-id 102Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Cerebellar control of movements is dependent on mossy fiber input conveying information about sensory and premotor activity in the spinal cord. While much is known about spino-cerebellar systems, which provide the cerebellum with detailed sensory information, much less is known about systems conveying motor information. Individual motoneurones do not have projections to spino-cerebellar neurons. Instead, the fastest route is from last order spinal interneurons. In order to identify the networks that convey ascending premotor information from last order interneurons, we have focused on the lateral reticular nucleus (LRN), which provides the major mossy fiber input to cerebellum from spinal interneuronal systems. Three spinal ascending systems to the LRN have been investigated: the C3-C4 propriospinal neurones (PNs), the ipsilateral forelimb tract (iFT) and the bilateral ventral flexor reflex tract (bVFRT). Voluntary forelimb movements involve reaching and grasping together with necessary postural adjustments and each of these three interneuronal systems likely contribute to specific aspects of forelimb motor control. It has been demonstrated that the command for reaching can be mediated via C3-C4 PNs, while the command for grasping is conveyed via segmental interneurons in the forelimb segments. Our results reveal convergence of ascending projections from all three interneuronal systems in the LRN, producing distinct combinations of excitation and inhibition. We have also identified a separate descending control of LRN neurons exerted via a subgroup of cortico-reticular neurones. The LRN projections to the deep cerebellar nuclei exert a direct excitatory effect on descending motor pathways via the reticulospinal, vestibulospinal, and other supraspinal tracts, and might play a key role in cerebellar motor control. Our results support the hypothesis that the LRN provides the cerebellum with highly integrated information, enabling cerebellar control of complex forelimb movements.

sted, utgiver, år, opplag, sider
2015. Vol. 9, artikkel-id 102
Emneord [en]
interneurons, propriospinal neurons, motoneurons, lateral reticular nucleus, cerebellum, motor ntrol, efferent copy, internal feedback
HSV kategori
Identifikatorer
URN: urn:nbn:se:umu:diva-108465DOI: 10.3389/fncom.2015.00102ISI: 000360180900001PubMedID: 26300768OAI: oai:DiVA.org:umu-108465DiVA, id: diva2:855645
Tilgjengelig fra: 2015-09-22 Laget: 2015-09-11 Sist oppdatert: 2018-06-07bibliografisk kontrollert

Open Access i DiVA

fulltext(7798 kB)211 nedlastinger
Filinformasjon
Fil FULLTEXT01.pdfFilstørrelse 7798 kBChecksum SHA-512
610b60cf75f321bea906e2f1747078a34cd34e94e738bbed8ced7298ec1dc2d7b96d7500c0116878c7079edb917274a985cb75ee7e56c7b6ca3a074b26e0fcab
Type fulltextMimetype application/pdf

Andre lenker

Forlagets fulltekstPubMed

Søk i DiVA

Av forfatter/redaktør
Alstermark, Bror
Av organisasjonen
I samme tidsskrift
Frontiers in Computational Neuroscience

Søk utenfor DiVA

GoogleGoogle Scholar
Totalt: 211 nedlastinger
Antall nedlastinger er summen av alle nedlastinger av alle fulltekster. Det kan for eksempel være tidligere versjoner som er ikke lenger tilgjengelige

doi
pubmed
urn-nbn

Altmetric

doi
pubmed
urn-nbn
Totalt: 519 treff
RefereraExporteraLink to record
Permanent link

Direct link
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf