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Pattern of microbial translocation in patients living with HIV-1 from Vietnam, Ethiopia and Sweden
Division of Clinical Microbiology, Department of Laboratory Medicine F68, Karolinska University Hospital, Stockholm, Sweden.ORCID-id: 0000-0003-0902-508X
Department of Medicine, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden.
Department of Medicine, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden.
Infectious Diseases Department, Bach Mai Hospital, Hanoi, Viet Nam .
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2014 (Engelska)Ingår i: Journal of the International AIDS Society, ISSN 1758-2652, E-ISSN 1758-2652, Vol. 17, s. 18841-Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

INTRODUCTION: The role of microbial translocation (MT) in HIV patients living with HIV from low- and middle-income countries (LMICs) is not fully known. The aim of this study is to investigate and compare the patterns of MT in patients from Vietnam, Ethiopia and Sweden.

METHODS: Cross-sectional samples were obtained from treatment-naïve patients living with HIV-1 and healthy controls from Vietnam (n=83; n=46), Ethiopia (n=9492; n=50) and Sweden (n=51; n=19). Longitudinal samples were obtained from a subset of the Vietnamese (n=24) in whom antiretroviral therapy (ART) and tuberculostatics were given. Plasma lipopolysaccharide (LPS), sCD14 and anti-flagellin IgG were determined by the endpoint chromogenic Limulus Amebocyte Assay and enzyme-linked immunosorbent assay.

RESULTS: All three biomarkers were significantly increased in patients living with HIV-1 from all countries as compared to controls. No differences were found between males and females. Vietnamese and Ethiopian patients had significantly higher levels of anti-flagellin IgG and LPS, as compared to Swedes. ART reduced these levels for the Vietnamese. Vietnamese patients given tuberculostatics at initiation of ART had significantly lower levels of anti-flagellin IgG and higher sCD14. The biomarkers were lower in Vietnamese who did not develop opportunistic infection.

CONCLUSIONS: Higher MT is common in patients living with HIV compared to healthy individuals, and in patients from LMICs compared to patients from a high-income country. Treatment with tuberculostatics decreased MT while higher levels of MT are associated with a poorer clinical outcome.

Ort, förlag, år, upplaga, sidor
2014. Vol. 17, s. 18841-
Nyckelord [en]
HIV in Ethiopia; HIV in Sweden; HIV in Vietnam; Immune activation; LPS; Microbial translocation; sCD14; Treatment-naïve patients living with HIV
Nationell ämneskategori
Infektionsmedicin Immunologi inom det medicinska området
Forskningsämne
Infektionssjukdomar; Immunologi
Identifikatorer
URN: urn:nbn:se:oru:diva-41998DOI: 10.7448/IAS.17.1.18841ISI: 000330631300001PubMedID: 24461466Scopus ID: 2-s2.0-84896819433OAI: oai:DiVA.org:oru-41998DiVA, id: diva2:792886
Forskningsfinansiär
Sida - Styrelsen för internationellt utvecklingssamarbeteVetenskapsrådet, 521-2012-3476
Anmärkning

Funding Agencies:

European and Developing Countries Clinical Trial Partnership

Swedish Civil Contingencies Agency SWE-2009-151

Tillgänglig från: 2015-03-05 Skapad: 2015-01-16 Senast uppdaterad: 2018-06-18Bibliografiskt granskad

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