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The locus C11orf30 increases susceptibility to poly-sensitization
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2015 (Engelska)Ingår i: Allergy. European Journal of Allergy and Clinical Immunology, ISSN 0105-4538, E-ISSN 1398-9995, Vol. 70, nr 3, s. 328-333Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

A number of genetic variants have been associated with allergic sensitization, but whether these are allergen specific or increase susceptibility to poly-sensitization is unknown. Using data from the large multicentre population-based European Community Respiratory Health Survey, we assessed the association between 10 loci and specific IgE and skin prick tests to individual allergens and poly-sensitization. We found that the 10 loci associate with sensitization to different allergens in a nonspecific manner and that one in particular, C11orf30-rs2155219, doubles the risk of poly-sensitization (specific IgE/4 allergens: OR = 1.81, 95% CI 0.80-4.24; skin prick test/4+ allergens: OR = 2.27, 95% CI 1.34-3.95). The association of rs2155219 with higher levels of expression of C11orf30, which may be involved in transcription repression of interferon-stimulated genes, and its association with sensitization to multiple allergens suggest that this locus is highly relevant for atopy.

Ort, förlag, år, upplaga, sidor
2015. Vol. 70, nr 3, s. 328-333
Nationell ämneskategori
Immunologi inom det medicinska området
Identifikatorer
URN: urn:nbn:se:uu:diva-245740DOI: 10.1111/all.12557ISI: 000349298100011PubMedID: 25546184OAI: oai:DiVA.org:uu-245740DiVA, id: diva2:791409
Tillgänglig från: 2015-02-27 Skapad: 2015-02-27 Senast uppdaterad: 2018-01-11Bibliografiskt granskad

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Janson, Christer
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Lungmedicin och allergologi
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Allergy. European Journal of Allergy and Clinical Immunology
Immunologi inom det medicinska området

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